Late effects after stem cell transplantation (SCT) in children - growth and hormones
Late effects after stem cell transplantation (SCT) in children - growth and hormones
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DOI：
10.1038/sj.bmt.1704853
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发表时间：
2005-03-01
影响因子：
4.8
通讯作者：
Niethammer, D
中科院分区：
文献类型：
--
作者：
Ranke, MB;Schwarze, CP;Niethammer, D
干细胞移植 (SCT) 已成为一种非常成功的治疗方法，可治疗通常无法战胜的疾病。然而，在儿童和青少年的一部分中，会出现迟发效应，通常是潜在疾病、其主要治疗和随后的 SCT 的综合作用。在儿童和青少年中，生长和内分泌系统疾病经常发生。保证正常生长、青春期、生育能力和甲状腺功能——包括预防继发性恶性肿瘤——对于治疗的整体成功和生活质量的维持至关重要。然而，这需要对 SCT 后的患者进行系统且结构化的随访计划。患者及其家人需要尽早熟悉这一概念，医生需要了解这样的系统必须作为综合护理的一部分实施。
Stem cell transplantation (SCT) has established itself as a very successful therapy in often otherwise unbeatable disorders. In a subset of children and adolescents there are, how ever, late effects, often as a combination of the underlying disorder, its primary treatment and subsequent SCT. In children and adolescents, disorders of growth and the endocrine system have been observed to occur frequently. The assurance of normal growth, puberty, fertility and thyroid function - including the prevention of secondary malignancies - is of utmost importance for the overall success of treatment and the maintenance of quality of life. This, how ever, requires a systematic and structured follow-up programme for patients after SCT. Patients and their families need to be made familar with this concept early and physicians need to understand that such a system must be implemented as part of a comprehensive care.