Enantio- and diastereoselective, stereospecific Mannich-type reactions in water
Enantio- and diastereoselective, stereospecific Mannich-type reactions in water
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DOI：
10.1021/ja048607t
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发表时间：
2004-06-30
影响因子：
15
通讯作者：
Kodayashi, S
中科院分区：
文献类型：
--
作者：
Hamada, T;Manabe, K;Kodayashi, S
使用znf2和芳香环上有甲氧基的手性二胺的组合，在水中催化不对称曼尼奇型反应以高收率和高选择性进行。在这些反应中，从(E)-或(Z)-硅烯醇酯中立体特异性地获得了合成或反曼尼希加合物，这与大多数不对称曼尼希型反应不同。
Catalytic asymmetric Mannich-type reactions in water proceeded in high yields and selectivities using a combination of ZnF2and a chiral diamine that has the methoxy groups on the aromatic rings. In these reactions, eithersyn- oranti-Mannich adducts were stereospecifically obtained from (E)- or (Z)-silicon enolate, in contrast with most asymmetric Mannich-type reactions.