A quest for initiating cells of head and neck cancer and their treatment.
A quest for initiating cells of head and neck cancer and their treatment.
复制标题
DOI：
10.3390/cancers2031528
复制
发表时间：
2010-07-27
期刊：
影响因子：
5.2
通讯作者：
Albers AE
中科院分区：
文献类型：
--
作者：
Chen C;Köberle B;Kaufmann AM;Albers AE
头颈部鳞状细胞癌（HNSCC）和其他癌症的生物学与癌症干细胞样细胞（CSC）有关。CSC的特异性标志物根据肿瘤类型或起源组织而变化很大。CSC是癌症的起始、持续和大多数静止。与大块肿瘤相比，CSC对化疗和放疗不太敏感，并且可能具有低免疫原性。CSC的治疗靶向可能改善临床结果。HNSCC有两个主要病因：人乳头瘤病毒，一种感染上皮干细胞的病毒，以及烟草和酒精滥用。在这里，目前的知识HNSCC-CSC生物学进行审查，并在必要时绘制一个全面的图片与其他来源的CSC的相似之处。
The biology of head and neck squamous cell carcinomas (HNSCC) and other cancers have been related to cancer stem-like cells (CSC). Specific markers, which vary considerably depending on tumor type or tissue of origin, characterize CSC. CSC are cancer initiating, sustaining and mostly quiescent. Compared to bulk tumors, CSC are less sensitive to chemo- and radiotherapy and may have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome. HNSCC has two main etiologies: human papillomavirus, a virus infecting epithelial stem cells, and tobacco and alcohol abuse. Here, current knowledge of HNSCC-CSC biology is reviewed and parallels to CSC of other origin are drawn where necessary for a comprehensive picture.