PANTOTHENIC ACID METABOLISM DURING AVIAN MALARIA INFECTION - PANTOTHENATE KINASE ACTIVITY IN DUCK ERYTHROCYTES AND IN PLASMODIUM LOPHURAE
PANTOTHENIC ACID METABOLISM DURING AVIAN MALARIA INFECTION - PANTOTHENATE KINASE ACTIVITY IN DUCK ERYTHROCYTES AND IN PLASMODIUM LOPHURAE
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DOI：
10.1111/j.1550-7408.1967.tb01985.x
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发表时间：
1967-01-01
期刊：
影响因子：
--
通讯作者：
TRAGER, W
中科院分区：
文献类型：
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作者：
BENNETT, TP;TRAGER, W
泛酸生成辅酶A途径中的起始酶反应，即：例如，在禽红细胞提取物中发现了由泛酸激酶催化的泛酸向磷酸泛酸的转化，但在疟原虫或完整寄生虫的提取物中没有发现。正常鸭红细胞提取物中的激酶活性显著高于感染P.lophurae的鸭红细胞提取物。在P.lophurae中明显缺乏泛酸激酶是营养研究的确证支持，营养研究表明禽疟疾寄生虫依赖于宿主细胞上辅酶A的供应。
The initial enzymatic reaction in the pathway of coenzyme A genesis from pantothenic acid, i. e., the conversion of pantothenic acid to phosphopantothenic acid catalyzed by pantothenic acid kinase, was found in extracts of avian erythrocytes but not in extracts of Plasmodium lephurae or intact parasites. The activity of the kinase was significantly higher in extracts prepared from normal duck erythrocytes than those infected with P. lophurae. The apparent absence of pantothenic acid kinase in P. lophurae is corroborative support for nutritional studies which suggest that the avian malarial parasite is dependent for its supply of coenzyme A on the host cell.