Self-organized signaling in stem cell models of embryos.
Self-organized signaling in stem cell models of embryos.
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DOI：
10.1016/j.stemcr.2021.03.020
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发表时间：
2021-05-11
影响因子：
5.9
通讯作者：
Warmflash A
中科院分区：
文献类型：
--
作者：
Liu L;Warmflash A
哺乳动物胚胎发育是一个复杂的自组织驱动过程。了解受精卵如何发育成由200多种细胞类型组成的胚胎，仍然是生物学的基本挑战之一。多能干细胞已被用作研究哺乳动物发育的体外模型，并代表再生疗法的有前途的构件。最近，已经开发出了复杂的基于干细胞的模型，该模型概括了早期胚胎的命运模式和形态发生。在这篇文章中，我们回顾了胚胎干细胞模型的最新进展，特别是侧重于支持细胞命运决定的信号活动在空间和时间。在这篇文章中，Liu和Warmflash讨论了基于干细胞的胚胎模型的最新进展，特别关注支持细胞命运决定的形态发生信号通路。在体外的2D和3D模型的胚胎和他们在体内的同行之间的信号活动的深入比较突出了这些新兴的模型的价值，了解自组织的信号动力学在哺乳动物胚胎发生。
Mammalian embryonic development is a complex process driven by self-organization. Understanding how a fertilized egg develops into an embryo composed of more than 200 cell types in precise spatial patterns remains one of the fundamental challenges in biology. Pluripotent stem cells have been used as in vitro models for investigating mammalian development, and represent promising building blocks for regenerative therapies. Recently, sophisticated stem cell-based models that recapitulate early embryonic fate patterning and morphogenesis have been developed. In this article, we review recent advances in stem cell models of embryos in particular focusing on signaling activities underpinning cell fate decisions in space and time. In this article, Liu and Warmflash discuss recent advances in stem cell-based models of embryos in particular focusing on morphogen signaling pathways underpinning cell fate decisions. In-depth comparisons of signaling activities between in vitro 2D and 3D models of embryos and their in vivo counterparts highlight the value of these emerging models for understanding self-organized signaling dynamics during mammalian embryogenesis.
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