A polymorphism of serotonin 2A receptor (5-HT2AR) influences delay discounting
A polymorphism of serotonin 2A receptor (5-HT2AR) influences delay discounting
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DOI：
10.1016/j.paid.2017.03.011
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发表时间：
2018-01-15
影响因子：
4.3
通讯作者：
Ohtsubo, Yohsuke
中科院分区：
文献类型：
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作者：
Ishii, Keiko;Matsunaga, Masahiro;Ohtsubo, Yohsuke
本研究调查了5-羟色胺2A受体(5-HT2AR)基因的多态与被称为延迟折扣的冲动选择形式之间的关联。在假设的情况下，我们让日本参与者在立即收到(或支付)不同数额的钱和特定延迟(一周、两周、一个月、六个月、一年、五年或25年)之间做出选择，并估计了跨期选择模型的参数(指数、双曲线、指数双曲线和准双曲线)。无论是哪种类型，总以最小AICC(小样本修正Akaike信息准则)表示的带指数双曲线模型比其他模型对观测数据的拟合效果更好。未来的收益被贴现的幅度比未来的损失更大。此外，正如预期的那样，携带5-HT2ARA-1438G多态的AA基因的个体比携带GG基因的个体对未来的折扣更大，尽管这种影响仅限于收益。这一发现表明，基于A-1438G多态的5-羟色胺在延迟折扣背后的奖励评估中的调制存在个体差异。(C)2017爱思唯尔有限公司。保留所有权利。
The present study investigated the association between a polymorphism of the serotonin 2A receptor (5-HT2AR) gene and the form of impulsive choice known as delay discounting. Using a hypothetical situation, we asked Japanese participants to choose between receiving (or paying) a different amount of money immediately or with a specified delay (one week, two weeks, one month, six months, one year, five years, or 25 years), and estimated the parameters of intertemporal choice models (exponential, hyperbolic, hyperbolic with exponent, and quasi hyperbolic). Regardless of the genotypes, the hyperbolic with exponent model, which always indicated minimum AICc (Akaike Information Criterion with small sample correction), fitted better the observed data than the other models. Future gains were discounted more steeply than future losses. Moreover, as expected, individuals with the AA genotype of the 5-HT2AR A-1438G polymorphism discounted the future more steeply than did individuals with the GG genotype, although this effect was limited to only gains. The findings implied individual differences based on the A-1438G polymorphism in the modulation of serotonin in the reward valuation underlying delay discounting. (C) 2017 Elsevier Ltd. All rights reserved.