ABILITY TO SMELL ANDROSTENONE IS GENETICALLY-DETERMINED
ABILITY TO SMELL ANDROSTENONE IS GENETICALLY-DETERMINED
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DOI：
10.1073/pnas.81.15.4899
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
BEAUCHAMP, GK
中科院分区：
文献类型：
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作者：
WYSOCKI, CJ;BEAUCHAMP, GK
一些成年人不能检测到雄烯酮（5 α-雄烯酮）的气味。雄甾-16-烯-3-酮），一种挥发性类固醇。为了测试与这一特征相关的遗传变异的存在，研究人员测试了成年双胞胎闻到雄烯酮和另一种气味剂吡啶的能力，这种气味剂很容易被大多数成年人感知。使用递增浓度、双样本（气味与空白）强迫选择测试来评估对这些气味剂的敏感性。同卵和异卵双胞胎检测阈值吡啶类内相关性小，没有显着差异。然而，雄烯酮阈值的组内相关性显着不同，同卵双胞胎的相关性大于异卵双胞胎。这些数据表明，对这种气味的敏感性变化的遗传成分。利用遗传变异的研究可以为嗅觉传导机制的研究提供一种新的工具。
Some adult humans cannot detect the odor of androstenone (5.alpha.-androst-16-en-3-one), a volatile steroid. To test for the presence of genetic variance associated with this trait, adult twins were tested for their ability to smell androstenone and another odorant, pyridine, that is readily perceived by most adults. Ascending concentration, 2-sample (odor vs. blank) forced choice tests were used to assess sensitivity to these odorants. Intraclass correlations for identical and fraternal twin detection thresholds to pyridine were small and not significantly different. However, intraclass correlations for thresholds to androstenone were significantly different, with the correlation for identical twins being greater than that for the fraternal twins. These data indicate a genetic component of variation in sensitivity to this odor. Investigations that use genetic variation could offer a new tool for studies of olfactory transduction mechanisms.