INCREASED DIETARY CALCIUM LOWERS BLOOD-PRESSURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT
INCREASED DIETARY CALCIUM LOWERS BLOOD-PRESSURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT
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DOI：
10.1016/0026-0495(79)90136-7
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发表时间：
1979-01-01
影响因子：
9.8
通讯作者：
AYACHI, S
中科院分区：
文献类型：
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作者：
AYACHI, S
通过从4周龄开始喂养实验室用碳酸钙（2.5%Ca，hCa [高Ca]）强化的饲料，研究了增加膳食Ca对自发性高血压（SH）大鼠高血压发展的影响。对照SH组喂食常规实验室食物（1.2%Ca，rCa [常规钙]）。两组年龄匹配的Wistar-Kyoto（WKY）大鼠平行治疗。采用尾袖法每周测量收缩压（BP），直至18周龄。hCa饮食显着衰减SH大鼠的高血压的时间进程，即使SH组最终发展为高血压。hCa也降低了WKY的BP，但程度较小。尿量（24小时量）不受hCa，但在SH和WKY组喂食hCa饮食，排泄的Na+，K+和Ca 2+显着升高，在11，15和19周龄。尿渗透压也升高。血浆Na+，Ca 2+和渗透压没有显着改变的饮食在SH或WKY大鼠;血浆K显着低于SH组喂食hCa饮食比rCa组。hCa饮食未显著影响身体或心脏、肾脏、肾上腺或胸腺重量。hCa饮食可通过诱导渗透性利尿来减轻遗传性高血压。
The effect of increased dietary Ca on the development of hypertension in spontaneously hypertensive (SH) rats was investigated by feeding lab show fortified with calcium carbonate (2.5% Ca, hCa [high Ca]) beginning at 4 wk of age. A control SH group was fed regular lab chow (1.2% Ca, rCa [regular calcium]). Two groups of age-matched Wistar-Kyoto (WKY) rats were treated in parallel. Systolic blood pressure (BP) was measured weekly until the age of 18 wk using a tail cuff method. The hCa diet significantly attenuated the time course of hypertension in SH rats even though both SH groups eventually developed hypertension. The hCa also lowered BP in WKYs, but to a lesser extent. Urine output (24 h volumes) was not affected by hCa, but in both SH and WKY groups fed the hCa diet, the excretion of Na+, K+ and Ca2+ was markedly elevated at 11, 15 and 19 wk of age. Urine osmolarity was also elevated. Plasma Na+, Ca2+ and osmolarity were not significantly altered by the diet in either SH or WKY rats; plasma K was significantly lower in the SH group fed the hCa diet than in the group given rCa. The hCa diet did not significantly affect the body or heart, kidney, adrenal or thymus weights. The hCa diet may attenuate genetic hypertension by inducing an osmotic diuresis.