Change in excitability of a putative decision-making neuron in Aplysia serves as a mechanism in the decision not to feed following food satiation
Change in excitability of a putative decision-making neuron in Aplysia serves as a mechanism in the decision not to feed following food satiation
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DOI：
10.1016/j.bbr.2014.12.022
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发表时间：
2015-03-15
影响因子：
2.7
通讯作者：
Mozzachiodi, Riccardo
中科院分区：
文献类型：
--
作者：
Dickinson, Kathy J.;Wainwright, Marcy L.;Mozzachiodi, Riccardo
虽然决策是一种普遍存在的功能，但对其潜在机制的理解仍然有限，特别是在单细胞水平上。在这项研究中，我们利用海洋软体动物海兔吃饱后不进食的决定来检查推定的决策神经元B51在这一过程中的作用。B51是摄食神经回路中的一个神经元，它在体外表现出决策特征，使回路偏向于产生负责咬行为的运动程序。一旦饱足，当食物刺激通常会刺激未饱足动物进食时，Aesthesia决定长时间（>= 24小时）不咬人。饱食后24小时，与未进食动物的对照组相比，抑制进食伴随着B51兴奋性的显著降低。在饱足组和对照组之间，B51静息膜特性或对B51的突触输入无差异。当在摄食已经从饱足的抑制作用恢复的时间点测量B51特性时（即，饱食后96 h），饱食组和对照组之间没有观察到B51兴奋性的差异。这些研究结果表明，B51兴奋性的变化的方式是一致的修改，在咬食物饱，从而暗示这个神经元作为一个网站的可塑性决定不咬食物饱后，在厌食症。(C)2014爱思唯尔有限公司版权所有。
Although decision making is a ubiquitous function, the understanding of its underlying mechanisms remains limited, particularly at the single-cell level. In this study, we used the decision not to feed that follows satiation in the marine mollusk Aplysia to examine the role of putative decision-making neuron B51 in this process. B51 is a neuron in the feeding neural circuit that exhibits decision-making characteristics in vitro, which bias the circuit toward producing the motor programs responsible for biting behavior. Once satiated, Aplysia decided not to bite for a prolonged period of time (>= 24h) when presented with a food stimulus that normally elicits feeding in non-satiated animals. Twenty-four hours after satiation, suppressed feeding was accompanied by a significant decrease of B51 excitability compared to the control group of unfed animals. No differences were measured in B51 resting membrane properties or synaptic input to B51 between the satiated and control groups. When B51 properties were measured at a time point in which feeding had recovered from the suppressive effects of satiation (i.e., 96 h after satiation), no difference in B51 excitability was observed between satiated and control groups. These findings indicate that B51 excitability changes in a manner that is coherent with the modifications in biting resulting from food satiation, thus implicating this neuron as a site of plasticity underlying the decision not to bite following food satiation in Aplysia. (C) 2014 Elsevier B.V. All rights reserved.