[Experimental study of the effect of cobalt irradiation on the rabbit lung].
[Experimental study of the effect of cobalt irradiation on the rabbit lung].
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钴辐照对兔肺影响的实验研究[J].
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
L. Bardou
中科院分区：
文献类型：
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作者：
M. Bellet;L. Barthélémy;J. Labat;P. Gendre;L. Bardou
用独特剂量的3150拉德CO60照射兔肺。从照射结束至照射后28天的肺泡毛细血管膜超微结构变化的时间相关性研究显示，早期病变首先累及内皮，其次是上皮和表面活性物质，累及间质最晚。病变过程在第7天达到最大，在接下来的三周内出现间质受累并扩大，而细胞受累则完全消退。对受照射肺洗涤液中磷脂的定性研究表明，表面活性剂组成的早期变化（卵磷脂含量下降，结构相似的物质外观），然后在第21天左右恢复到几乎正常的组成。表面活性剂的这种早期变化的性质是有争议的：它是表面活性剂分泌的变化和/或表面活性剂合成过程的早期变化？
Rabbit lungs were irradiated with a unique dose of 3,150 rads of CO60. The time related study (from the end of irradiation to 28 days after-wards) of the ultrastructural changes in the alveolo-capillary membrane, shows that the early lesions involve first of all the endothelium, then the epithelium and the surfactant, interstitial involvement being the latest. The course of the lesions is maximal on the 7th day, while interstitial involvement appears and is amplified in the three following weeks, whereas cellular involvement completely regresses. Qualitative study of phospholipids from the pulmonary washing fluid of the irradiated lung shows early changes in the composition of surfactant (fall in lecithins and appearance of substances with similar structure) then a return to a practically normal composition around the 21st day. The nature of this early change in surfactant is debated: is it a change in surfactant secreted and/or an early change in the process of synthesis of surfactant?