Lymph Nodes Metastasis is a Risk Factor for Bone Metastasis from Extrahepatic Cholangiocarcinoma
Lymph Nodes Metastasis is a Risk Factor for Bone Metastasis from Extrahepatic Cholangiocarcinoma
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DOI：
10.5754/hge11806
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发表时间：
2012-09-01
影响因子：
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通讯作者：
Unno, Michiaki
中科院分区：
文献类型：
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作者：
Katayose, Yu;Nakagawa, Kei;Unno, Michiaki
背景/目的：胆管癌骨转移的发生率、部位及预后尚不清楚。因此，我们打算对骨转移的背景进行比较性综述，检查骨转移的高危人群，并将数据用于改善生活质量。方法：收集我科2003年1月至2010年4月手术切除的200例胆管癌病例。结果：骨转移4例（2.0%）。骨转移后生存期2.9 ~ 21.6个月，平均6.7个月。我们研究了骨转移、淋巴结转移、淋巴管浸润、血管浸润和神经周围浸润（ly、v和pn）的组织病理学表现，发现4例骨转移病例均为淋巴结转移阳性，淋巴结转移是影响骨转移的一个有统计学意义的因素。结论：由于我们研究的病例数量较少，很难确定淋巴结转移是否是骨转移的危险因素;但是，我们认为在为淋巴结转移阳性患者提供医疗护理时，有必要考虑骨转移的可能性。
Background/Aims: The rate and site of bone metastasis from cholangiocarcinoma as well as the prognosis are unclear. Therefore, we intend to make a comparative review of the background to bone metastasis, examine a high-risk group for bone metastasis and use the data towards the improvement in quality of life. Methodology: We studied 200 cases of cholangiocarcinoma resected in our division from January 2003 to April 2010. Results: Bone metastasis was confirmed in four cases (2.0%). The survival period after the diagnosis of bone metastasis ranged from 2.9 months to 21.6 months and the average was 6.7 months. We studied histopathological findings of bone metastasis, lymph node metastasis, lymphatic invasion, blood vessel invasion and perineural invasion (ly, v and pn) and found that all of four bone metastasis cases were positive for lymph node metastasis which was a statistically significant factor affecting bone metastasis. Conclusions: Since the number of cases we studied is small, it is difficult to determine whether lymph node metastasis is a risk factor for bone metastasis; however, we think it is necessary to take the probability of bone metastasis into consideration when we provide medical care to patients positive for lymph node metastasis.