Socioeconomic factors influence selection and participation in a population-based case-control study of head and neck cancer in Scotland
Socioeconomic factors influence selection and participation in a population-based case-control study of head and neck cancer in Scotland
复制标题
DOI：
10.1016/j.jclinepi.2007.12.012
复制
发表时间：
2008-11-01
影响因子：
7.2
通讯作者：
McKinney, Patricia A.
中科院分区：
文献类型：
--
作者：
Conway, David I.;McMahon, Alex D.;McKinney, Patricia A.
目的：我们的目的是探讨社会经济因素和选择和参与偏见之间的关联在人口为基础的病例对照研究的头部和颈部癌症进行的城市的格拉斯哥，UK.Methods：一般做法（GP）的情况下，受试者的抽样框架，从年龄和性别匹配的控制被随机选择。病例和对照组的参与者和非参与者邮政编码与基于地区的苏格兰多重痴呆指数相关。比较研究的选择和参与与格拉斯哥研究的基础population.Results：情况下，显着更贫困地区比对照。总体而言，病例组（34.9%）和对照组（34.7%）的参与率均较低。我们的总体对照样本与格拉斯哥从贫困地区“过度选择”的一般人群不相似。个人从更富裕的地区更有可能参与提供一组受访的参与者反映了社会经济分布的格拉斯哥。结论：低参与率的病例对照研究仍然是一个问题，社会经济因素强烈影响参与。在一个方向上偏向的控制样本选择被相反方向上的参与偏差所抵消-偶然地提供了一个代表性的控制样本。从病例GP列表中选择对照需要谨慎实施，注意获得GP人群潜在社会经济特征的证据，特别是对于社会经济分布不均衡的疾病。(C)2008年爱思唯尔公司All rights reserved.
Objective: We aimed to investigate the association between socioeconomic factors and selection and participation biases in a population-based case-control study of head and neck cancer conducted in the city of Glasgow, UK.Methods: General Practices (GP) of the case subjects were the sampling frame from which age and sex-matched controls were randomly selected. Participant and nonparticipant postcodes of cases and controls were linked to the area-based Scottish Index of Multiple Deprivation. Comparisons of study selection and participation were made with the Glasgow study-base population.Results: Cases were from significantly more deprived areas than controls. Overall, participation was low for both cases (34.9%) and controls (34.7%). Our overall control sample was not similar to the general population of Glasgow having "over selected" from deprived areas. Individuals from more affluent areas were more likely to participate providing a set of interviewed participants reflecting the socioeconomic distribution of Glasgow.Conclusions: Low participation rates in case-control studies remain a problem and socioeconomic factors strongly affect participation. A control sample selection biased in one direction was offset by participation bias in the opposite direction-fortuitously providing a representative control sample. Selecting controls from case GP lists needs to be implemented with care with attention paid to obtaining evidence on the underlying socioeconomic characteristics of GP populations, especially for diseases with a skewed socioeconomic distribution. (C) 2008 Elsevier Inc. All rights reserved.