Associations of work-related stress and total sleep time with cholesterol levels in an occupational cohort of Japanese office workers.
Associations of work-related stress and total sleep time with cholesterol levels in an occupational cohort of Japanese office workers.
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DOI：
10.1002/1348-9585.12275
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发表时间：
2021-01
影响因子：
3
通讯作者：
Svensson AK
中科院分区：
文献类型：
--
作者：
Meguro K;Svensson T;Chung UI;Svensson AK
本研究的目的是调查总睡眠时间（TST）和职业压力的基础上，简要的工作压力问卷（BJSQ）与胆固醇水平的日本办公室工作人员的职业队列的关联。本研究是对一项随机对照试验的一部分参与者进行的二次分析。参与者是来自东京5家公司的179名员工，他们作为干预组参加了一项为期3个月的生活方式干预研究，研究对象是患有代谢综合征或有代谢综合征风险的办公室工作人员。所有干预组参与者均使用移动的应用程序和可穿戴设备。本研究的最终分析人群为173名参与者。胆固醇指标来自参与者纳入研究前财年的年度健康检查数据。使用多元线性回归模型来确定暴露与结果之间的关联。总体而言，压力水平与LDL-C（−7.12 mg/dl; 95% CI：−11.78，−2.45）和LDL-C/HDL-C比率（−0.16 mg/dl; 95% CI：−0.27，−0.04）显著负相关。与平均TST 5.9 - 7.2小时相比，平均TST 4.0 - 5.3小时（−4.82 mg/dl; 95% CI：−9.22，−0.43）与HDL-C呈负相关。压力的递增与LDL-C和LDL-C/HDL-C比值显著负相关。最短平均TST与HDL-C呈负相关。考虑到某些方法上的局限性，对结果的解释应谨慎。
The aim of the study was to investigate the associations of total sleep time (TST) and occupational stress based on the Brief Job Stress Questionnaire (BJSQ) with cholesterol levels in an occupational cohort of Japanese office workers. The present study is a secondary analysis of a subset of participants from a randomized controlled trial. Participants were 179 employees from 5 companies in Tokyo who participated as the intervention group in a 3‐month lifestyle intervention study among office workers with metabolic syndrome or at risk of metabolic syndrome. All intervention‐group participants used a mobile app and a wearable device. The final population for analysis in the present study were 173 participants. Cholesterol measures were derived from participants' annual health check‐up data in the fiscal year preceding their inclusion in the study. Multiple linear regression models were used to determine the association between exposures and outcome. Overall, stress levels were significantly and inversely associated with LDL‐C (−7.12 mg/dl; 95% CI: −11.78, −2.45) and LDL‐C/HDL‐C ratio (−0.16 mg/dl; 95% CI: −0.27, −0.04) per standard deviation increase. Compared to average TST 5.9‐7.2 hours, average TST of 4.0‐5.3 hours (−4.82 mg/dl; 95% CI: −9.22, −0.43) was inversely associated with HDL‐C. Incremental increases of stress were significantly and inversely associated with LDL‐C and LDL‐C/HDL‐C ratio. The shortest average TST was inversely associated with HDL‐C. The results should be interpreted with care given certain methodological limitations.