Estimating the optimal dynamic antipsychotic treatment regime: Evidence from the sequential multiple assignment randomized CATIE Schizophrenia Study.
Estimating the optimal dynamic antipsychotic treatment regime: Evidence from the sequential multiple assignment randomized CATIE Schizophrenia Study.
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估计最佳动态抗精神病药物治疗方案：顺序多重分配的证据随机分配精神分裂症研究。
DOI：
10.1111/j.1467-9876.2012.01041.x
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发表时间：
2012-08-01
期刊：
影响因子：
--
通讯作者：
Moodie EE
中科院分区：
文献类型：
--
作者：
Shortreed SM;Moodie EE
Treatment of schizophrenia is notoriously difficult and typically requires personalized adaption of treatment due to lack of efficacy of treatment, poor adherence, or intolerable side effects. The Clinical Antipsychotic Trials in Intervention Effectiveness (CATIE) Schizophrenia Study is a sequential multiple assignment randomized trial comparing the typical antipsychotic medication, perphenazine, to several newer atypical antipsychotics. This paper describes the marginal structural modeling method for estimating optimal dynamic treatment regimes and applies the approach to the CATIE Schizophrenia Study. Missing data and valid estimation of confidence intervals are also addressed.
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