Is transcription in sperm stationary or dynamic?

Is transcription in sperm stationary or dynamic?
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精子中的转录是静态的还是动态的?

DOI:
10.1262/jrd.2016-093
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发表时间:
2017-10-18
期刊:
The Journal of reproduction and development
影响因子:
--
通讯作者:
Wang D
Wang D
中科院分区:
其他
文献类型:
--
作者:
Ren X;Chen X;Wang Z;Wang D

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由于精子发生过程中精子染色质的包装,转录活性受到抑制。然而,在精子中检测到大量转录本,引发了精子中是否存在转录事件的问题,这一直是最近研究的中心焦点。本文综述了精子发生过程中转录活性及精子中转录活性的研究进展,包括精子发生过程中转录水平的差异、精子运动能力不同的精子中转录水平的差异、获能和冷冻前后转录水平的差异。这将为研究精子中基因表达的机制(S)奠定理论基础,对于更好地利用动物父系和开发生殖控制技术将具有非常重要的价值。
Transcriptional activity is repressed due to the packaging of sperm chromatins during spermiogenesis. The detection of numerous transcripts in sperm, however, raises the question whether transcriptional events exist in sperm, which has been the central focus of the recent studies. To summarize the transcriptional activity during spermiogenesis and in sperm, we reviewed the documents on transcript differences during spermiogenesis, in sperm with differential motility, before and after capacitation and cryopreservation. This will lay a theoretical foundation for studying the mechanism(s) of gene expression in sperm, and would be invaluable in making better use of animal sires and developing reproductive control technologies.
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