Beneficial effects of citrus juice fermented with Lactobacillus plantarum YIT 0132 on atopic dermatitis: results of daily intake by adult patients in two open trials
Beneficial effects of citrus juice fermented with Lactobacillus plantarum YIT 0132 on atopic dermatitis: results of daily intake by adult patients in two open trials
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DOI：
10.12938/bmfh.2015-010
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发表时间：
2016-01-01
影响因子：
3.1
通讯作者：
Nakamura, Shinichiro
中科院分区：
文献类型：
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作者：
Harima-Mizusawa, Naomi;Kamachi, Keiko;Nakamura, Shinichiro
本研究旨在研究每天摄入含有热致死植物乳杆菌Yit 0132的柑橘汁(LP0132-发酵汁)是否能缓解特应性皮炎的症状。这是我们先前研究的自然延伸，在先前的研究中，LP0132被证明在体外可以促进IL-10的产生，LP0132发酵汁被发现可以缓解日本雪松花粉症患者的症状和提高生活质量(QOL)。在两个公开试验中，试验1和试验2，32名和18名患有轻中度特应性皮炎的成年患者分别饮用LP0132发酵果汁8周。在摄入果汁前(治疗前)、开始摄入果汁后8周(治疗后)、停止摄入8周后(治疗后)用Skindex-16对患者的皮肤状况和生活质量进行主观评估。并对血液参数进行分析。治疗和治疗后时间点与治疗前时间点的比较显示，在两个试验中，Skindex-16总分和3个领域分值(症状、情绪和功能领域)显著降低。此外，在试验2中，血中嗜酸性粒细胞阳离子蛋白(ECP)、总免疫球蛋白(IgE)和雪松、柏木花粉的特异性IgE水平显著降低。结果表明，每天摄入含有热致死LP0132的柑橘发酵汁对轻、中度特应性皮炎患者的症状和生活质量有有益的影响，这可能是通过降低IgE和ECP而起到免疫调节作用的。
This study aimed to examine whether daily intake of citrus juice containing heat-killed Lactobacillus plantarum YIT 0132 (LP0132-fermented juice) alleviates symptoms of atopic dermatitis. This was a natural extension of our previous study in which LP0132 was shown to enhance IL-10 production in vitro and LP0132-fermented juice was found to alleviate symptoms and enhance quality of life (QOL) in patients with Japanese cedar pollinosis. In two open trials, Trial 1 and Trial 2, 32 and 18 adult patients with mild to moderate atopic dermatitis consumed LP0132-fermented juice for 8 weeks. Skin conditions and QOL were subjectively evaluated using Skindex-16 before intake of the juice (Pretreatment), 8 weeks after starting intake (Treatment) and 8 weeks after termination of intake (Post-treatment). Blood parameters were also analyzed. Comparison of the Treatment and Post-treatment time points with the Pre-treatment time point revealed significant reductions in the Skindex-16 overall score and the 3 domain subscores (symptoms, emotions, and functioning domains) in both trials. Moreover, blood levels of eosinophil cationic protein (ECP), total immunoglobulin E (IgE) and specific IgEs for Japanese cedar and cypress pollen were significantly attenuated in Trial 2. The findings suggest that daily intake of citrus fermented juice containing heat-killed LP0132 has beneficial effects on symptoms and QOL in patients with mild to moderate atopic dermatitis due to an immunomodulatory effect via attenuation of IgE and ECP.