Smoking and the risk of diverticular disease in women
Smoking and the risk of diverticular disease in women
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DOI：
10.1002/bjs.7477
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发表时间：
2011-07-01
影响因子：
9.6
通讯作者：
Hakansson, N.
中科院分区：
文献类型：
--
作者：
Hjern, F.;Wolk, A.;Hakansson, N.
背景：吸烟与憩室疾病风险之间的关系尚不清楚。一项观察性队列研究旨在调查吸烟与憩室疾病之间的关系。方法：从1997年到2008年，对1914年至1948年出生的瑞典乳房x线摄影队列中的女性进行随访。通过问卷调查收集有关吸烟和其他生活方式因素的信息。症状性憩室疾病患者从瑞典国家登记册中确定。使用Cox比例风险模型估计吸烟状况导致症状性憩室疾病（导致住院或死亡）的相对风险（rr）。结果：在纳入研究的35809名妇女中，561名（1.6%）患有症状性憩室疾病。在多变量分析中，与不吸烟者相比，在调整了年龄、膳食纤维摄入量、糖尿病、高血压、使用乙酰水杨酸、非甾体抗炎药或类固醇药物、饮酒、体重指数、体育活动和教育水平后，当前吸烟者患症状性憩室疾病的风险增加（RR 1.23, 95%可信区间0.99至1.52）。过去的吸烟者也有增加的风险（RR = 1.26, 1.02 - 1.56）。吸烟者发生憩室穿孔/脓肿的风险高于不吸烟者（RR 1.89, 1.15至3.10）。结论：吸烟与症状性憩室病有关。
Background: The relationship between smoking and the risk of diverticular disease is unclear. An observational cohort study was undertaken to investigate the association between smoking and diverticular disease.Methods: Women in the Swedish Mammography Cohort born between 1914 and 1948 were followed from 1997 to 2008. Information on smoking and other lifestyle factors was collected through questionnaires. Patients with symptomatic diverticular disease were identified from Swedish national registers. Relative risks (RRs) of symptomatic diverticular disease (resulting in hospital admission or death) according to smoking status were estimated using Cox proportional hazards models.Results: Of 35 809 women included in the study, 561 (1.6 per cent) had symptomatic diverticular disease. In multivariable analysis, current smokers had an increased risk of symptomatic diverticular disease compared with non-smokers after adjustment for age, intake of dietary fibre, diabetes, hypertension, use of acetylsalicylic acid, non-steroidal anti-inflammatory drugs or steroid medication, alcohol consumption, body mass index, physical activity and level of education (RR 1.23, 95 per cent confidence interval 0.99 to 1.52). Past smokers also had an increased risk (RR 1.26, 1.02 to 1.56). Smokers had a higher risk of developing a diverticular perforation/abscess than non-smokers (RR 1.89, 1.15 to 3.10).Conclusion: Smoking is associated with symptomatic diverticular disease.