Change in colonic motility after extrinsic autonomic denervation in dogs
Change in colonic motility after extrinsic autonomic denervation in dogs
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DOI：
10.1023/a:1018827613809
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发表时间：
1997-09-01
影响因子：
3.1
通讯作者：
Tanaka, M
中科院分区：
文献类型：
--
作者：
Ishikawa, M;Mibu, R;Tanaka, M
在主动脉旁和骶前（A组）、主动脉旁（B组）或结肠系膜区（C组）和假手术（D组）的狗中比较结肠运动的变化。将五个双极记录电极放置在结肠和直肠的浆肌层中。A组胃内注射橄榄油后的连续电反应活动和收缩电复合波的数目少于其他组（P < 0.05），近端结肠运动也有显著性差异，提示盆丛在包括近端结肠在内的结肠运动中可能起重要作用。神经丛的损伤在剥脱后至少六个月没有恢复。盆腔神经丛损伤可能是直肠前切除术后排便习惯改变时间延长的原因之一。
Changes in colonic motility were compared in dogs undergoing autonomic denervation of the paraaortic and presacral (group A), paraaortic (group B), or mesocolonic region (group C), and sham operation (group D). Five bipolar recording electrodes were placed into the seromuscular layer of the colon and rectum. The numbers of continuous electrical response activity and contractile electrical complex after an intragastric olive oil injection were smaller in group A than in the other groups (P < 0.05) from three weeks through sire months after denervation, This difference was significant even in the proximal colon, These data suggest that the pelvic plexus may play an important rule in colonic motility including the proximal colon, The damage to the plexus did not recover for at least six months after denevation. Pelvic plexus injury may thus be one of possible explanations for the prolonged change in bowel habit after anterior resection of the rectum.