Anxiety-related behaviors in the elevated zero-maze are affected by genetic factors and retinal degeneration
Anxiety-related behaviors in the elevated zero-maze are affected by genetic factors and retinal degeneration
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DOI：
10.1037/0735-7044.115.2.468
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发表时间：
2001-04-01
影响因子：
1.9
通讯作者：
Flaherty, L
中科院分区：
文献类型：
--
作者：
Cook, MN;Williams, RW;Flaherty, L
在高架零迷宫中测试了8种近交系小鼠的焦虑水平，这些小鼠广泛用于生物医学和行为研究。应变差异观察到的活动，潜伏期进入一个开放的象限，开放时间，排便，表明遗传因素介导的焦虑在这个范例。其中三个菌株有导致视网膜变性的rdl突变，在迷宫中不那么焦虑。为了辨别视觉敏锐度是否是迷宫差异的来源，测试了rdl等位基因被野生型等位基因取代的同类品系的焦虑水平。同类菌株，视力正常。焦虑程度更高本研究提供了在迷宫药理学挑战中选择和使用任何这些菌株的基线数据。并为鉴定可能具有适当背景用于靶向突变研究的菌株提供了起点。
Anxiety levels were tested in an elevated zero-maze for 8 inbred strains of mice that are used widely in biomedical and behavioral research. Strain differences were observed for activity, latency to enter an open quadrant, open time, and defecation, demonstrating that genetic factors mediate anxiety in this paradigm. Three of the strains have the rdl mutation that causes retinal degeneration and were less anxious in the maze. To discern whether visual acuity is a source of difference on the maze, anxiety levels were tested in a congenic strain in which the rdl allele has been replaced with the wild-type allele. The, congenic strain, with normal vision. had higher levels of anxiety. This study provides baseline data for the selection and use of any of these strains in pharmacological challenges in the maze. and provides a starting point for the identification of strains that may have appropriate backgrounds for targeted mutation studies.