Pressor reflex response to static muscular contraction: its afferent arm and possible neurotransmitters.
Pressor reflex response to static muscular contraction: its afferent arm and possible neurotransmitters.
复制标题
对静态肌肉收缩的升压反射反应：其传入臂和可能的神经递质。
DOI：
10.1016/s0002-9149(88)80013-4
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Rybicki,KJ
中科院分区：
文献类型：
--
作者：
Kaufman,MP;Rotto,DM;Rybicki,KJ
静态肌肉收缩已被证明以反射的方式增加心血管和呼吸功能。该反射弧的感觉臂由III和IV类肌肉传入组成。对这些肌肉传入的放电特性进行了研究，这些肌肉传入的激活引起了收缩的升压反射反应。与IV组相比，III组传入神经对机械刺激(如肌腱拉伸和探测其感受野)的反应更强。相反，第三组传入神经元对缺血性收缩的反应不如第四组传入神经元。钾、乳酸和花生四烯酸均为收缩代谢产物，可刺激等比例的III、IV类传入神经。然而，腺苷、磷酸和乳酸对传入神经元的放电没有影响。鞘内注射P物质和生长抑素的拮抗剂或抗体可使收缩的升压反应减弱约一半，这一发现表明这两种多肽在反射的脊髓传递中发挥了作用。
Static muscular contraction has been shown to increase cardiovascular and ventilatory function in reflex manner. The sensory arm of this reflex arc is comprised of group III and IV muscle afferents. The discharge properties of these muscle afferents whose activation causes the pressor reflex response to contraction were investigated. Group III afferents were more responsive to mechanical stimuli, such as tendon stretch and probing their receptive fields than were group IV afferents. In contrast, group III afferents were less responsive to ischemic contraction than were group IV afferents. Equal percentages of group III and IV afferents were stimulated by potassium, lactic acid and arachidonic acid, each of which are metabolic products of contraction. Adenosine, phosphate and lactate, however, had no effect on the discharge of the afferents. Intrathecal injection of antagonists or antibodies to substance P and somatostatin attenuated the pressor response to contraction by about half, a finding that suggests a role for these 2 peptides in the spinal transmission of the reflex.