Concise Review: Emerging Drugs Targeting Epithelial Cancer Stem-Like Cells
Concise Review: Emerging Drugs Targeting Epithelial Cancer Stem-Like Cells
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DOI：
10.1002/stem.2579
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发表时间：
2017-04-01
期刊：
影响因子：
5.2
通讯作者：
Nateri, Abdolrahman Shams
中科院分区：
文献类型：
--
作者：
Ahmed, Mehreen;Chaudhari, Kritika;Nateri, Abdolrahman Shams
越来越多的证据表明，癌细胞群中含有一小部分具有干细胞样特性的细胞，这些细胞可能负责整体肿瘤的维持。这些癌症干细胞样细胞（CSC）似乎具有独特的肿瘤启动能力和先天的生存机制，使它们能够抵抗癌症治疗，从而促进复发。选择性靶向 CSC 可能会带来治疗益处，最近的几份报告表明这可能是可能的。在本文中，我们回顾了针对选定的上皮细胞衍生癌症中的 CSC 的药物。
Increasing evidence suggests that cancer cell populations contain a small proportion of cells that display stem-like cell properties and which may be responsible for overall tumor maintenance. These cancer stem-like cells (CSCs) appear to have unique tumor-initiating ability and innate survival mechanisms that allow them to resist cancer therapies, consequently promoting relapses. Selective targeting of CSCs may provide therapeutic benefit and several recent reports have indicated this may be possible. In this article, we review drugs targeting CSCs, in selected epithelial cell-derived cancers.