Maturation of mammalian spermatozoa: modifications of the acrosome and plasma membrane leading to fertilization
Maturation of mammalian spermatozoa: modifications of the acrosome and plasma membrane leading to fertilization
复制标题
DOI：
10.1007/s004410051110
复制
发表时间：
1998-07
影响因子：
3.6
通讯作者：
K. Toshimori
中科院分区：
文献类型：
--
作者：
K. Toshimori
哺乳动物精子是一种终末分化的细胞。它的表面覆盖着一层连续的质膜，质膜被分成不同的区域，功能分子分布在其中。顶体是位于头部前部的内部细胞器，含有水解酶。前顶体参与顶体反应，是受精过程中不可缺少的事件。这些表面结构域和顶体在精子发生期间形成，在此期间相关分子被运输和组织。许多这样排列的分子在功能上是不成熟的，但在附睾成熟过程中逐渐成熟。其中一些在受精过程中进一步改变和重新分配，并发挥各种作用。本文综述了精子成熟过程中顶体和质膜的连续变化，特别关注来自睾丸的分子。
The mammalian spermatozoon is a terminally differentiated cell. Its surface is covered by a continuous plasma membrane that is divided into distinct domains in which functional molecules are distributed. The acrosome is an internal organelle located at the anterior head and contains hydrolytic enzymes. The anterior acrosome participates in the acrosome reaction, which is an indispensable event during fertilization. These surface domains and the acrosome are formed during spermiogenesis, during which associated molecules are transported and organized. Many of the molecules thus arranged are functionally immature but gradually become mature during epididymal maturation. Some of them are further altered and redistributed during the fertilization process and play various roles. Here, the sequential changes in the acrosome and plasma membrane during spermatozoan maturation are reviewed, particular attention being paid to molecules derived from the testis.