Role of Skin pH in Psoriasis.
Role of Skin pH in Psoriasis.
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DOI：
10.1159/000489524
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发表时间：
2018-01-01
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影响因子：
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通讯作者：
Bigliardi, Paul L
中科院分区：
文献类型：
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作者：
Bigliardi, Paul L
关于皮肤pH值在皮肤病理生理学中的作用，特别是在银屑病中的作用知之甚少。然而，有令人信服的证据表明，表皮pH值可以影响皮肤稳态，并通过改变皮肤酶的活性和通过调节皮肤炎症和微生物定植来影响皮肤屏障。这包括分泌型磷脂酶A的激活以及与过氧化物酶体增殖物激活受体和类维生素A途径的相互作用。此外，皮肤中的pH影响水通道蛋白的活性，这控制表皮的水合作用。皮肤稳态、分化、屏障缺陷和炎症的变化在银屑病的发病机制中起着至关重要的作用。有证据表明，皮肤pH值可以影响所有这些重要因素。然而，需要更多的研究来客观和精确地检查银屑病皮损和非皮损皮肤中各个皮肤层的pH值，并将其与正常皮肤进行比较。这种额外的知识对于了解皮肤pH在银屑病中的作用至关重要，最终在银屑病管理中局部方法中皮肤pH的操纵具有巨大潜力。
Not much is known about the role of skin pH in skin pathophysiology, in particular in psoriasis. However, there is compelling evidence that the epidermal pH can influence the skin homeostasis and affect the skin barrier by changing the activity of cutaneous enzymes and through the modulation of skin inflammation and microbial colonization. This includes the activation of secretory phospholipase A and interaction with the peroxisome proliferators-activated receptor and retinoid pathways. In addition, pH in skin affects the activity of aquaporins and this controls the hydration of the epidermis. Changes in skin homeostasis, differentiation, barrier defects, and inflammation play a crucial role in the pathogenesis of psoriasis. There is evidence that skin pH can affect all of these important factors. However, more studies are needed to examine objectively and precisely the pH in the various skin layers in psoriatic lesional and non-lesional skin and compare it to normal skin. This additional know-how is essential to understand the role of skin pH in psoriasis with ultimately great potential of manipulations of skin pH for topical approaches in the management of psoriasis.