Cocaine self-administration and naltrindole, a delta-selective opioid antagonist.
Cocaine self-administration and naltrindole, a delta-selective opioid antagonist.
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可卡因自我给药和纳曲吲哚（一种 δ 选择性阿片拮抗剂）。
DOI：
10.1097/00001756-199507100-00012
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发表时间：
1995
期刊：
影响因子：
1.7
通讯作者：
Porreca,F
中科院分区：
文献类型：
--
作者：
Reid,LD;Glick,SD;Menkens,KA;French,ED;Bilsky,EJ;Porreca,F
最近来自几个实验室的报告表明，增量阿片受体在表达可卡因的一些生化和行为影响方面发挥了作用。在这里，通过评估大鼠在没有或存在选择性增量阿片拮抗剂纳曲哚的情况下自我注射可卡因的倾向，进一步探索了这种可能性。在几天稳定的可卡因摄入之后，在一天的疗程之前，纳曲哚(3或10毫克·公斤-1)减少了对可卡因的压迫，无论强化的时间表如何。这些数据进一步支持了与增量阿片受体相关的过程在可卡因加强自身使用能力方面的作用。
RECENT reports from several laboratories have suggested a role for delta opioid receptors in expressing some of the biochemical and behavioral effects of cocaine. Here, this possibility has been further explored by evaluating the propensity of rats to self-administer iv cocaine in the absence or presence of naltrindole, a selective delta opioid antagonist. Following a number of days of stable cocaine intake, and before a day's session, naltrindole (3 or 10 mg kg-1) reduced pressing for cocaine, regardless of the schedule of reinforcement. These data further support the role of processes associated with delta opioid receptors in the ability of cocaine to reinforce its own use.