First-pass perfusion CMR two days after infarction predicts severity of functional impairment six weeks later in the rat heart.
First-pass perfusion CMR two days after infarction predicts severity of functional impairment six weeks later in the rat heart.
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DOI：
10.1186/1532-429x-13-38
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发表时间：
2011-08-03
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影响因子：
--
通讯作者：
Clarke K
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文献类型：
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作者：
Stuckey DJ;Carr CA;Meader SJ;Tyler DJ;Cole MA;Clarke K
在人类中，钆基造影剂第一次灌注的动态对比CMR已成为识别心脏灌注不足区域的标准技术，可以准确显示心肌梗死的严重程度。尽管该方法具有重要的临床意义，但很少应用于心脏疾病的小动物模型。为了识别梗死大鼠心脏的灌注延迟，在这里，我们提出了一种在每个心动周期获得T1加权MR图像的方法。在离体灌注的大鼠心脏中，造影剂输注在整个心肌中给予均匀的信号增强。左冠状动脉前降支闭塞显著降低了心脏前区信号增强率，表明首过法对灌注缺陷很敏感。心肌梗死后2天、8天进行心肌形态、功能、灌注和活力测定。在第42天使用电影mri进一步评估形态学和功能。灌注延迟在大鼠心脏中更大，继续发展为更大的功能损害，表明首过CMR可以用作梗死严重程度的早期指标。梗死后2天和8天的第一次CMR比心脏射血分数、舒张末期容积或收缩末期容积更能预测预后。首次通过CMR提供了一种预测心力衰竭啮齿动物模型梗死引起的心肌损害严重程度的方法。
In humans, dynamic contrast CMR of the first pass of a bolus infusion of Gadolinium-based contrast agent has become a standard technique to identify under-perfused regions of the heart and can accurately demonstrate the severity of myocardial infarction. Despite the clinical importance of this method, it has rarely been applied in small animal models of cardiac disease. In order to identify perfusion delays in the infarcted rat heart, here we present a method in which a T1 weighted MR image has been acquired during each cardiac cycle. In isolated perfused rat hearts, contrast agent infusion gave uniform signal enhancement throughout the myocardium. Occlusion of the left anterior descending coronary artery significantly reduced the rate of signal enhancement in anterior regions of the heart, demonstrating that the first-pass method was sensitive to perfusion deficits. In vivo measurements of myocardial morphology, function, perfusion and viability were made at 2 and 8 days after infarction. Morphology and function were further assessed using cine-MRI at 42 days. The perfusion delay was larger in rat hearts that went on to develop greater functional impairment, demonstrating that first-pass CMR can be used as an early indicator of infarct severity. First-pass CMR at 2 and 8 days following infarction better predicted outcome than cardiac ejection fraction, end diastolic volume or end systolic volume. First-pass CMR provides a predictive measure of the severity of myocardial impairment caused by infarction in a rodent model of heart failure.