Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis
Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis
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DOI：
10.1080/17474124.2018.1416291
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发表时间：
2018-01-01
影响因子：
3.9
通讯作者：
Lin, Qin
中科院分区：
文献类型：
--
作者：
Wu, San-Gang;Chen, Xue-Ting;Lin, Qin
背景：本研究的目的是根据原发肿瘤位置调查印戒细胞癌 (SRCC) 患者的生存情况。方法：从监测、流行病学和最终结果数据库 (1988-2012) 中获得患者数据，每个肿瘤位置≥200 例。 Cox 回归分析用于调查特定原因生存 (CSS) 的预后因素。结果：我们确定了 24,171 名患者。在患者中，63.4%患有胃SRCC，其次是结肠（18.2%）、食管（5.0%）、直肠（3.5%）、肺（3.1%）、胰腺（1.8%）、乳腺（1.5%）、膀胱（1.3%）、小肠（1.1%）和胆囊SRCC（1.0%）。胃、乳腺、结肠、直肠、膀胱、小肠、食管、胆囊、肺和胰腺 SRCC 患者的 5 年 CSS 分别为 22.1%、69.0%、33.2%、28.1%、24.8%、16.1%、13.6%、12.6%、11.0%、6.4%（P < 0.001）。多变量分析表明，原发肿瘤位置是生存的独立预后因素。肺、小肠和膀胱 SRCC 患者的 CSS 与胃 SRCC 相当，而乳腺癌和结直肠 SRCC 的生存率比胃 SRCC 更好。与胃 SRCC 相比，食管、胆囊和胰腺 SRCC 与较差的 CSS 显着相关。结论：我们的研究表明，根据原发肿瘤位置，SRCC 的生存率存在重大差异。
Background: The aim of this study was to investigate the survival of patients with signet ring cell carcinoma (SRCC) based on primary tumor location.Methods: Patient data were obtained from the Surveillance, Epidemiology, and End Results database (1988-2012) with >= 200 cases per tumor location. Cox regression analysis was used to investigate prognostic factors of cause-specific survival (CSS).Results: We identified 24,171 patients. Of the patients, 63.4% had gastric SRCC, followed by colon (18.2%), esophageal (5.0%), rectal (3.5%), lung (3.1%), pancreatic (1.8%), breast (1.5%), bladder (1.3%), small intestine (1.1%), and gallbladder SRCC (1.0%). The 5-year CSS was 22.1%, 69.0%, 33.2%, 28.1%, 24.8%, 16.1%, 13.6%, 12.6%, 11.0%, 6.4% in patients with gastric, breast, colon, rectum, bladder, small intestine, esophageal, gallbladder, lung, and pancreatic SRCC, respectively (P < 0.001). Multivariate analyses showed that the primary tumor location was an independent prognostic factor of survival. Patients with lung, small intestine, and bladder SRCC had a comparable CSS to gastric SRCC, while breast and colorectal SRCC had better survival than gastric SRCC. Esophageal, gallbladder, and pancreatic SRCC were significantly associated with poor CSS compared with gastric SRCC.Conclusion: Our study suggests a major difference in survival of SRCC based on the primary tumor locations.