Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction
Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction
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DOI：
10.1161/01.res.0000050588.35034.3c
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发表时间：
2003-01-10
影响因子：
20.1
通讯作者：
Matsumoto, T
中科院分区：
文献类型：
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作者：
Iuchi, T;Akaike, M;Matsumoto, T
糖皮质激素（GC）过量通常会对血管系统产生严重的不良影响，如高血压和动脉粥样硬化，而对这些并发症的有效预防是有限的。我们试图揭示gc诱导血管并发症的机制。与GC治疗前（130+/-14%）相比，20例GC治疗患者前臂血流对反应性充血的反应显著降低至43+/-8.9%（平均+/-SEM）。服用维生素C几乎使血流反应恢复正常。在人脐静脉内皮细胞（HUVECs）中，经过10(-7)mol/L地塞米松（DEX）处理，过氧化氢的产量增加到对照组的166.5+/-3.3%
Glucocorticoid (GC) excess often elicits serious adverse effects on the vascular system, such as hypertension and atherosclerosis, and effective prophylaxis for these complications is limited. We sought to reveal the mechanism underlying GC-induced vascular complications. Responses in forearm blood flow to reactive hyperemia in 20 GC-treated patients were significantly decreased to 43+/-8.9% (mean+/-SEM) from the values obtained before GC therapy (130+/-14%). An administration of vitamin C almost normalized blood flow responses. In human umbilical vein endothelial cells (HUVECs), production of hydrogen peroxide was increased up to 166.5+/-3.3% of control values by 10(-7) mol/L dexamethasone (DEX) treatment (P