Does osteoporosis classification using heel BMD agree across manufacturers?
Does osteoporosis classification using heel BMD agree across manufacturers?
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DOI：
10.1007/s001980200082
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发表时间：
2002-01-01
影响因子：
4
通讯作者：
Genant, HK
中科院分区：
文献类型：
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作者：
Grigorian, M;Shepherd, JA;Genant, HK
已知骨矿物质密度（BMD）测量缺乏标准化。已经进行了几项研究来交叉校准轴向双X射线吸收测定法（DXA）设备。最近，已经引入了许多外围DXA（pDXA）密度计。在这项研究中，我们评估了两种足跟DXA设备之间的BMD和T分数的协议。共有99名年龄在21-78岁之间的女性（约100人）。16/10）使用PIXI（Lunar Inc.）和Apollo（Norland Medical）pDXA扫描仪。PIXI和Apollo的平均BMD值分别为0.492和0.607 g/cm（2），使用制造商指定的参考数据得出的平均T评分分别为-0.07和-0.25。BMD和T评分机间关系高度相关，但显示出显着的非同一性斜率和非零偏移。T评分的诊断比较结果显示，两种仪器之间的一致率为86%（加权Kappa评分为0.550）。使用本研究的年轻成人人群BMD结果对参考峰和SD进行归一化，消除了系统性T评分不一致。我们发现PIXI和Apollo高度相关。BMD值的差异主要是由于不同的感兴趣区域（ROI）定义和额外的T评分不一致反映了标准数据库中的差异。
The lack of standardization in bone mineral density (BMD) measurements is known. Several studies have been carried out to cross-calibrate the axial dual Xray absorptiometry (DXA) devices. Recently, a number of peripheral DXA (pDXA) densitometers have been introduced. In this study we evaluated the agreement between two heel DXA devices on BMD and T-scores. A total of 99 females aged 21-78 years (ca. 16 per decade) had their non-dominant heel BMD measured using the PIXI (Lunar Inc.) and the Apollo (Norland Medical) pDXA scanners. The mean BMD values were 0.492 and 0.607 g/cm(2) and the mean T-scores using manufacturers' specified reference data were - 0.07 and - 0.25 for the PIXI and Apollo, respectively. Both the BMD and T-score intermachine relationships were highly correlated but showed significant nonidentity slopes and non-zero offsets. The diagnostic comparison on T-scores resulted in 86% agreement between the instruments (weighted kappa score of 0.550). Normalizing the reference peaks and SDs using this study's young adult population BMD results removed the systematic T-score disagreement. We found that PIXI and Apollo are highly correlated. Differences in BMD values are mainly due to different region of interest (ROI) definitions and additional T-score disagreement reflects the difference in normative databases.