Metabolic profiles in ovulatory and anovulatory primiparous dairy cows during the first follicular wave postpartum
Metabolic profiles in ovulatory and anovulatory primiparous dairy cows during the first follicular wave postpartum
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DOI：
10.1262/jrd.18105
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发表时间：
2007-02-01
影响因子：
1.8
通讯作者：
Miyamoto, Akio
中科院分区：
文献类型：
--
作者：
Kawashima, Chiho;Sakaguchi, Minoru;Miyamoto, Akio
代谢激素影响奶牛的卵巢功能。然而，在产后初产奶牛中，代谢因素与卵巢功能之间的关系尚不清楚，因为它们仍在生长中。本研究的目的是详细研究排卵和无排卵初产奶牛产后第一个卵泡波期间代谢激素、代谢产物和产奶量随时间的变化规律。选用16头初产荷斯坦奶牛，每隔一天采血测定代谢产物(葡萄糖、非酯化脂肪酸、酮体、总胆固醇和天冬氨酸氨基转移酶)、代谢激素(生长激素、胰岛素样生长因子-1和胰岛素)和孕酮的含量。此外，对所有卵巢进行了超声观察。在试验期间记录奶牛的产奶量。所有奶牛产后第一次出现卵泡波，有6头奶牛排卵。无排卵奶牛的血糖(P<；0.0001)和胰岛素样生长因子-1(P<；0.001)浓度低于排卵奶牛，血浆NEFA(P<；0.0001)和酮体(P<；0.0001)浓度和日产奶量(P<；0.0001)高于排卵奶牛。然而，生长激素水平在两组之间没有差异，生长激素水平可以促进产奶量、胰岛素和其他代谢物的脂肪分解。综上所述，本研究表明，初产奶牛产后第一个卵泡波中优势卵泡的无排卵是由与经产奶牛相似的低IGF-1水平引起的。此外，与排卵奶牛相比，无排卵奶牛可能更容易调动体内脂肪储备来生产牛奶。
Metabolic hormones affect ovarian function in the cow. However, the relationship between metabolic factors and ovarian function is not clear in the postpartum primiparous cow because they are still growing. The aim of the present study was to investigate in detail the time-dependent profile of the metabolic hormones, metabolites, and milk yields of ovulatory and anovulatory primiparous cows during the first follicular wave postpartum. We used 16 primiparous Holstein cows and obtained blood samples for the profiles of metabolites (glucose; non-esterified fatty acid, NEFA; ketone body; total cholesterol; and aspartate aminotransferase), metabolic hormones (growth hormone, GH; insulin-like growth factor-I, IGF-1; and insulin), and progesterone every other day from I to 21 days postpartum. In addition, all ovaries were observed using ultrasound. Dairy milk yield was recorded during the experimental period. In all cows, the first follicular wave postpartum was observed and 6 of the cows ovulated. The plasma glucose (P < 0.0001) and IGF-1 (P < 0.001) concentrations were lower and the plasma NEFA (P < 0.0001) and ketone bodies (P < 0.0001) concentrations and daily milk yield (P < 0.0001) were higher in the anovulatory cows compared to the ovulatory cows. However, the GH levels, which enhance lipolysis for milk production, insulin and other metabolites did not differ between the two groups. In conclusion, the present study suggests that anovulation of the dominant follicle during the first follicular wave postpartum in primiparous cows is induced by low IGF-1 levels that are similar to those of multiparous cows. In addition, anovulatory cows are likely to mobilize body fat stores for milk production more easily than ovulatory cows.