The role of anterior midcingulate cortex in cognitive motor control: evidence from functional connectivity analyses.
The role of anterior midcingulate cortex in cognitive motor control: evidence from functional connectivity analyses.
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DOI：
10.1002/hbm.22363
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发表时间：
2014-06
影响因子：
4.8
通讯作者：
Eickhoff SB
中科院分区：
文献类型：
--
作者：
Hoffstaedter F;Grefkes C;Caspers S;Roski C;Palomero-Gallagher N;Laird AR;Fox PT;Eickhoff SB
吻侧扣带皮层与许多认知控制功能有关。最近的神经影像学数据表明，前中扣带皮层（aMCC）在运动产生的认知方面起着关键作用，即有意识的运动控制。本文采用两种互补的方法来测试该区域的功能连通性：(1)基于100名受试者的fMRI扫描的aMCC静息状态连通性；(2)使用656个成像实验的元分析连通性模型（MACM）在明确任务条件下的功能连通性。两种方法均揭示了aMCC与前额叶、运动前皮层、顶叶皮层以及前脑岛、44/45区、小脑和背纹状体的功能网络结构趋同。为了明确测试aMCC的任务型功能连通性在认知运动控制中的作用，分别对“认知”和“行动”相关的实验范式进行了MACM分析。两项分析都证实了aMCC基于任务的相同连接模式。“认知”领域在前额叶皮层和脑岛前部的模态上关联区显示出较高的活动收敛，而“动作”相关实验在体感和前运动区显示出较高的活动收敛。其次，为了探究aMCC收敛性功能连接的功能特异性，将其与意向运动启动神经网络进行了比较。这一典型的比较证实了aMCC的状态独立FC网络参与有意运动的产生。综上所述，本研究的不同实验表明，aMCC是网络中实现有意运动控制的关键区域。
The rostral cingulate cortex has been associated with a multitude of cognitive control functions. Recent neuroimaging data suggest that the anterior midcingulate cortex (aMCC) has a key role for cognitive aspects of movement generation, i.e., intentional motor control. We here tested the functional connectivity of this area using two complementary approaches: (1) resting-state connectivity of the aMCC based on fMRI scans obtained in 100 subjects, and (2) functional connectivity in the context of explicit task conditions using meta-analytic connectivity modeling (MACM) over 656 imaging experiment. Both approaches revealed a convergent functional network architecture of the aMCC with prefrontal, premotor and parietal cortices as well as anterior insula, area 44/45, cerebellum and dorsal striatum. To specifically test the role of the aMCC’s task-based functional connectivity in cognitive motor control, separate MACM analyses were conducted over “cognitive” and “action” related experimental paradigms. Both analyses confirmed the same task-based connectivity pattern of the aMCC. While the “cognition” domain showed higher convergence of activity in supramodal association areas in prefrontal cortex and anterior insula, “action” related experiments yielded higher convergence in somatosensory and premotor areas. Secondly, to probe the functional specificity of the aMCC’s convergent functional connectivity, it was compared with a neural network of intentional movement initiation. This exemplary comparison confirmed the involvement of the state independent FC network of the aMCC in the intentional generation of movements. In summary, the different experiments of the present study suggest that the aMCC constitute a key region in the network realizing intentional motor control.