Distribution of polyhexylcyanoacrylate nanoparticles in nude mice over extended times and after repeated injection.
Distribution of polyhexylcyanoacrylate nanoparticles in nude mice over extended times and after repeated injection.
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DOI：
10.1002/jps.2600770305
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发表时间：
1988-03
影响因子：
3.8
通讯作者：
E. Gipps;P. Groscurth;J. Kreuter;P. Speiser
中科院分区：
文献类型：
--
作者：
E. Gipps;P. Groscurth;J. Kreuter;P. Speiser
将直径在200-300 nm之间的碳-14标记的聚氰基丙烯酸酯纳米颗粒静脉注射到裸鼠体内。用液体闪烁计数法研究其在肝、脾、肺、心、肾、胃肠道、性腺、脑、肌肉和血清中的分布。一次注射后，放射性标记清除缓慢，28d后残留45%，140d后残留8%，间隔28d(两次或三次)重复注射后，脾和肺的剂量比例高于其他器官。未观察到肝、脾或肺的组织学改变。
Carbon-14-labeled polyhexylcyanoacrylate nanoparticles, with diameters between 200 and 300 nm, were injected intravenously into nude mice. The distribution in liver, spleen, lung, heart, kidney, GI tract, gonads, brain, muscle, and serum was investigated by liquid scintillation counting. After a single injection, the radiolabel was cleared slowly with 45% remaining after 28 d and 8% remaining after 140 d. After repeated injection with an interval of 28 d (twice or thrice), relatively higher proportions of the dose were found in the spleen and lung as compared with those in other organs. No histological alterations were observed in the liver, spleen, or lung.