Degradation potential of plasma-sprayed hydroxyapatite-coated titanium implants.
Degradation potential of plasma-sprayed hydroxyapatite-coated titanium implants.
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等离子喷涂羟基磷灰石涂层钛植入物的降解潜力。
DOI：
10.1002/jbm.820291206
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Nancollas,GH
中科院分区：
文献类型：
--
作者：
Paschalis,EP;Zhao,Q;Tucker,BE;Mukhopadhayay,S;Bearcroft,JA;Beals,NB;Spector,M;Nancollas,GH
本研究的目的是发展一种分析方法来评估等离子喷涂羟基磷灰石（HAP）涂层的溶解行为。本研究中使用了六种市售和临床使用的涂层，这些涂层根据骨科器械各自的质量标准应用于无孔钛试样。首先在37°C下将植入物置于0.15 mol L− 1氯化钠溶液中预处理，直至达到平衡或溶液中氢离子和钙离子浓度达到预期变化，从而监测溶解行为。在第二步中，植入物在受控欠饱和条件下进行双恒定组成（DCC）溶解。结果表明，尽管包括X射线衍射和FTIR在内的分析技术表明溶液处理前后涂层的结晶度或组成没有变化，但HAP涂层的溶解速率可能相差多达5倍。这些结果表明，来自不同来源的HAP涂层在放置在相同的局部水性环境中时反应非常不同。然而，在这些体外结果可以用于预测体内行为之前，还需要更多的工作。John Wiley & Sons，Inc.
The purpose of this study was to develop an analytical method for evaluating the dissolution behavior of plasmasprayed hydroxyapatite (HAP) coatings. Six commercially available and clinically used coatings applied to nonporous titanium coupons according to their respective specifications for orthopedic devices were used in this study. Dissolution behavior was monitored by first preconditioning the implant in 0.15 mol L−1sodium chloride solution at 37°C until either equilibrium or the desired change in solution hydrogen and calcium ion concentrations had been reached. In the second step, the implants were subjected to dual constant composition (DCC) dissolution under conditions of controlled undersaturation. Results indicate that the dissolution rates of the HAP coatings may differ by as much as a factor of 5 despite the fact that analytical techniques, including X‐ray diffraction and FTIR, indicate no change in crystallinity or composition of the coatings before and after the solution treatment. These results indicate that HAP coatings from different sources react very differently when placed in the same local aqueous environment. However, more work will be necessary before thesein vitroresults can be used to predictin vivobehavior. © 1995 John Wiley & Sons, Inc.