CANCER STAGE-TO-AGE RELATIONSHIP - IMPLICATIONS FOR CANCER SCREENING IN THE ELDERLY
CANCER STAGE-TO-AGE RELATIONSHIP - IMPLICATIONS FOR CANCER SCREENING IN THE ELDERLY
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DOI：
10.1111/j.1532-5415.1981.tb01227.x
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发表时间：
1981-01-01
影响因子：
6.3
通讯作者：
HEARNE, E
中科院分区：
文献类型：
--
作者：
HOLMES, FF;HEARNE, E
在一项专门研究年龄-分期关系的研究中，研究了30,991例癌症按疾病分期与确诊时患者年龄的分布情况。对于膀胱癌、乳腺癌、子宫颈癌、卵巢癌和子宫内膜癌，进展期与高龄呈高度正相关(P<；0.001)。对于肾癌和胃癌，这种关系仍然存在，但没有那么显著(P<；0.05)。对于结直肠癌，没有明显的关系。对于支气管癌，存在非常显著的负相关关系(P<；0.001)。在癌症起源部位之后，诊断时的阶段是治疗和生存的下一个最重要的决定因素。这些数据强调了定期盆腔检查的重要性，将其作为筛查老年妇女无症状宫颈癌、卵巢癌或其他子宫(子宫内膜)癌的手段。这些数据支持了乳房自我检查和乳房X光检查在老年女性乳腺癌筛查中的重要性。在肺癌患者中，年龄与分期呈负相关，这表明定期胸片和细胞学痰检查可能更适合老年人，而不是年轻人群，因为这些筛查方法在年轻人中被证明是令人失望的。
In a study specifically addressing the age-stage relationship, the distribution of 30,991 cancers by disease-stage vs. patient-age at diagnosis was examined. For cancer of the bladder, breast, cervix, ovary and uterus (endometrium), a highly significant positive relationship was found between advancing stage and advancing age (P < 0.001). For cancer of the kidney and stomach, the relationship held but was less significant (P < 0.05). For colorectal cancer, no relationship was evident. For bronchial cancer there was a highly significant inverse relationship (P < 0.001). After the site of origin of the cancer, the stage at the time of diagnosis was the next most important determinant for treatment and survival. These data emphasize the importance of periodic pelvic examination as a means of screening for asymptomatic cervical, ovarian or other uterine (endometrial) cancer in elderly women. The data support the importance of breast self-examination and mammography in screening for breast cancer in older women. The inverse relationship of age to stage in bronchial cancer suggests that screening by periodic chest roentgenograms and cytologic sputum examinations may be more appropriate for elderly than for younger populations in whom these screening methods have proved disappointing.