The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: Results from the postmenopausal estrogen/progestin interventions mammographic density study
The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: Results from the postmenopausal estrogen/progestin interventions mammographic density study
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DOI：
10.1093/aje/kwi286
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发表时间：
2005-11-01
影响因子：
5
通讯作者：
Reboussin, BA
中科院分区：
文献类型：
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作者：
Greendale, GA;Palla, SL;Reboussin, BA
乳房X线密度是乳腺癌的独立危险因素。在绝经后女性中，内源性类固醇水平较高与乳腺癌风险增加有关。有限的先前数据表明，内源性类固醇与较高的乳房X线照相密度要么不相关（总雌二醇和黄体酮），要么呈负相关（游离雌二醇）。为了分析内源性类固醇与乳房 X 光密度之间的关联，作者对 1998 年至 2005 年绝经后雌激素/孕激素干预 (PEPI) 试验的基线临床试验数据进行了横断面分析，该试验的对象是在基线前至少 3.1 个月未使用激素治疗的美国女性。在根据年龄、体重指数、产次、先前使用激素治疗、自上次使用激素治疗以来的时间以及先前使用激素治疗与自上次使用激素治疗以来的时间之间的相互作用进行调整的模型中，雌酮（β = 0.0013，p = 0.014）、雌二醇（β = 0.0009，p = 0.009）和生物可利用雌二醇（β = 0.0021，p = 0.009）水平较高。 0.018）与更大的乳房X线照相密度具有统计学显着相关性。 （β 系数表示每种激素每单位增量 (pg/ml) 的乳房 X 线照相密度增量。）这些结果表明，某些性类固醇可能通过刺激乳腺上皮或基质增殖（在乳房 X 光照片上显示为更高的密度）来增加患乳腺癌的风险。
Mammographic density is an independent risk factor for breast cancer. In postmenopausal women, higher levels of endogenous sex steroids are associated with an increased risk of breast cancer. Limited prior data suggest that endogenous sex steroids either are not associated (total estradiol and progesterone) or are negatively associated (free estradiol) with higher mammographic density. To analyze the associations between endogenous sex steroids and mammographic density, the authors conducted a 1998-2005 cross-sectional analysis of baseline clinical trial data from the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial for US women who had not used hormone therapy for at least 3.1 months prior to baseline. In models adjusted for age, body mass index, parity, prior use of hormone therapy, time since last use of hormone therapy, and the interaction between prior hormone therapy use and time since last hormone therapy use, higher levels of estrone (beta = 0.0013, p = 0.014), estradiol (beta = 0.0009, p = 0.009), and bioavailable estradiol (beta = 0.0021, p = 0.018) were statistically significantly related to greater mammographic density. (Beta coefficients express the increment in mammographic density per-unit increment (pg/ml) of each hormone.) These results suggest that some sex steroids may increase the risk of breast cancer by stimulating breast epithelial or stromal proliferation, which appears on a mammogram as higher density.