Importance of interphase nucleolar organizer regions in tumor pathology
Importance of interphase nucleolar organizer regions in tumor pathology
复制标题
间期核仁组织区在肿瘤病理学中的重要性
DOI：
10.1007/bf02890399
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
D. Treré
中科院分区：
文献类型：
--
作者：
M. Derenzini;D. Treré
摘要已经综述了间期核中银染核仁组织区 (Ag-NOR) 的分布对于肿瘤病理学诊断和预后目的的重要性。现有数据表明，间期 Ag-NOR 评估可能有助于区分恶性细胞与增生或正常细胞。另一方面，越来越多的证据表明间期Ag-NOR的数量与恶性肿瘤的预后存在关系：间期Ag-NOR的数量越多，预后越差。这可以通过观察到间期Ag-NOR的量与细胞增殖率严格相关来解释。还对用于测量间相 Ag-NOR 量的程序进行了批判性讨论。
SummaryThe importance of the distribution of silverstained nucleolar organizer regions (Ag-NORs) in interphase nuclei for diagnostic and prognostic purposes in tumor pathology has been reviewed. The available data demonstrated that interphase Ag-NOR evaluation may be of help in distinguishing malignant from hyperplastic or normal cells. On the other hand, there is increasing evidence that a relationship exists between the quantity of interphase Ag-NORs and the prognosis of malignant tumors: the greater the number of interphase Ag-NORs, the worse is the prognosis. This can be explained by the observation that the interphase Ag-NOR quantity is strictly related to the cell proliferation rate. The procedures used for the measurement of the interphase Ag-NOR quantity are also critically discussed.