Antioxidative and renoprotective effects of residue polysaccharides from Flammulina velutipes
Antioxidative and renoprotective effects of residue polysaccharides from Flammulina velutipes
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DOI：
10.1016/j.carbpol.2016.03.071
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发表时间：
2016-08-01
影响因子：
11.2
通讯作者：
Jia, Le
中科院分区：
文献类型：
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作者：
Lin, Lin;Cui, Fangyuan;Jia, Le
从金针菇残渣中提取Ac-RPS、Al-RPS和En-RPS三种可提取多糖，研究其对STZ诱导小鼠的抗氧化和肾脏保护作用。生化和抗氧化分析表明，En-RPS具有显著降低血清CRE、BUN、ALB和GLU水平，显著提高肾脏SOD、CAT和GSH-Px活性，显著降低肾脏MDA含量的潜在作用。此外，组织病理学观察还显示，En-RPS可以减轻肾损伤。这些结果表明，从F.结果表明，金针菇具有较强的抗氧化活性，有望成为糖尿病肾病的治疗药物。此外，还对这三种RPS的单糖组成进行了分析。(C)2016爱思唯尔有限公司版权所有
Three extractable polysaccharides including Ac-RPS, Al-RPS and En-RPS were extracted from the residue of Flammulina velutipes and their antioxidative and renoprotective effects on STZ-induced mice were investigated. Biochemical and antioxidant analysis showed that the En-RPS had potential effects in decreasing the serum levels of CRE, BUN, ALB and GLU significantly, increasing the renal activities of SOD, CAT and GSH-Px remarkably, and reducing the renal contents of MDA prominently. Furthermore, the histopathological observations also displayed that En-RPS could alleviate kidney damage. These results demonstrated that En-RPS extracted from the residue of F. velutipes possessed potent antioxidant activities, and could be used as a promising therapeutic agent for inhibiting the progression of diabetic nephropathy. In addition, the monosaccharide compositions of these three RPS were also analyzed. (C) 2016 Elsevier Ltd. All rights reserved.