Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks
Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks
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DOI：
10.1016/j.lfs.2014.05.015
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发表时间：
2014-07-25
期刊：
影响因子：
6.1
通讯作者：
Furuse, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Erwan, Edi;Chowdhury, Vishwajit Sur;Furuse, Mitsuhiro
目的：L-天冬氨酸（L-Asp）和D-天冬氨酸（CD-Asp）是哺乳动物和鸟类重要的生理氨基酸。然而，这些氨基酸的功能尚未完全了解。因此，在本研究中，我们研究了L-Asp和D-Asp对雏鸡体温、血浆代谢产物和猫胆碱的调节作用。主要方法：鸡首先口服不同剂量的（0，3.75，7.5和15 mmol/kg体重）Asp来监测这些氨基酸在120 mm的实验期间对直肠温度的影响。经口给予D-Asp而不是L-Asp线性降低了雏鸡的直肠温度。重要的是，即使在高环境温度（HT）条件下，口服D-Asp也会导致雏鸡体温显著降低。然而，集中管理的D-Asp没有显着影响鸡的体温。至于血浆代谢产物和儿茶酚胺，口服给药D-Asp导致降低甘油三酯和尿酸浓度和增加葡萄糖和氯浓度，但没有改变血浆catecholamines.Significance：这些结果表明，口服给药D-Asp可能发挥有效的作用，在正常和HT条件下降低体温。血浆代谢产物的变化进一步表明D-Asp可能参与了雏鸡代谢活动的调节。(C)2014 Elsevier Inc. All rights reserved.
Aims: L-Aspartate (L-Asp) and D-aspartate CD-Asp) are physiologically important amino acids in mammals and birds. However, the functions of these amino acids have not yet been fully understood. In this study, we therefore examined the effects of L-Asp and D-Asp in terms of regulating body temperature, plasma metabolites and cat-echolamines in chicks.Main methods: Chicks were first orally administered with different doses (0, 3.75, 7.5 and 15 mmol/kg body weight) of L- or D-Asp to monitor the effects of these amino acids on rectal temperature during 120 mm of the experimental period.Key findings: oral administration of D-Asp, but not of L-Asp, linearly decreased the rectal temperature in chicks. Importantly, orally administered D-Asp led to a significant reduction in body temperature in chicks even under high ambient temperature (HT) conditions. However, centrally administered D-Asp did not significantly influence the body temperature in chicks. As for plasma metabolites and catecholamines, orally administered D-Asp led to decreased triacylglycerol and uric acid concentrations and increased glucose and chlorine concentrations but did not alter plasma catecholamines.Significance: These results suggest that oral administration of D-Asp may play a potent role in reducing body temperature under both normal and HT conditions. The alteration of plasma metabolites further indicates that D-Asp may contribute to the regulation of metabolic activity in chicks. (C) 2014 Elsevier Inc. All rights reserved.