Quasi-spherical silver nanoparticles: Aqueous synthesis and size control by the seed-mediated Lee-Meisel method
Quasi-spherical silver nanoparticles: Aqueous synthesis and size control by the seed-mediated Lee-Meisel method
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DOI：
10.1016/j.jcis.2012.12.037
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发表时间：
2013-03-15
影响因子：
9.9
通讯作者：
Gu, Ning
中科院分区：
文献类型：
--
作者：
Wan, Yu;Guo, Zhirui;Gu, Ning
银纳米粒子（AgNPs）在生物医学领域引起了广泛的关注，其相关性能与形状和尺寸有关。对于生物医学应用，水溶性AgNPs是必要的。然而，由于成核和生长之间的平衡难以调节，具有受控形状和尺寸的AgNP的水相合成相对困难。本文描述了一种基于种子介导生长和柠檬酸盐热还原AgNO 3的Lee-Meisel方法相结合的可控合成准球形AgNP的稳健方法。在所提出的方法中，柠檬酸盐稳定的AgNPs与可调的大小达到80 nm，通过一步或分步生长过程中使用合格的球形4 nm AgNPs作为起始种子。特别是，通过调整反应温度和晶种量等实验参数，在不添加添加剂、不调节pH值和不进行激光处理的情况下，有效地克服了以往研究中存在的两个主要困难（纳米棒的形成和生长阶段的二次成核）。讨论了影响银纳米粒子均匀性的关键因素。(C)2012 Elsevier Inc. All rights reserved.
Silver nanoparticles (AgNPs) are attracting tremendous attention in biomedicine, and their related performances are shape and size-dependent. For biomedical applications, water-soluble AgNPs are necessary. However, aqueous syntheses of AgNPs with controlled shape and size are relatively difficult as the balance between nucleation and growth is hard to regulate. This paper describes a robust method for controllable synthesis of quasi-spherical AgNPs based on the combination of the seed-mediated growth and the Lee-Meisel method by thermal reduction of AgNO3 with citrate. In the presented method, citrate-stabilized AgNPs with tunable sizes up to 80 nm were achieved through one-step or stepwise growth process using qualified spherical 4 nm AgNPs as starter seeds. Specially, the two main difficulties (formation of nanorods and secondary nucleation during the growth stage) in the previous studies have been effectively overcome by tailoring the experimental parameters such as the reaction temperature and the seed amount, without extra additives, pH adjustment, and laser treatment. The crucial factors that affect the uniformity of the resulting AgNPs are discussed. (C) 2012 Elsevier Inc. All rights reserved.