Transdiagnostic psychiatric disorder risk associated with early age of menarche: A latent modeling approach.
Transdiagnostic psychiatric disorder risk associated with early age of menarche: A latent modeling approach.
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与初潮过早相关的跨诊断精神疾病风险：一种潜在的建模方法。
DOI：
10.1016/j.comppsych.2017.06.010
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发表时间：
2017
影响因子：
7.3
通讯作者：
Keyes,KatherineM
中科院分区：
文献类型：
--
作者：
Platt,JonathanM;Colich,NatalieL;McLaughlin,KatieA;Gary,Dahsan;Keyes,KatherineM
研究背景与按时或晚成熟的女性相比，青春期成熟年龄较早的女性在青春期出现心理健康问题的风险增加。然而，大多数关于青春期时间和心理健康的研究考虑了个体疾病的风险，而没有考虑合并症。一个潜在的建模方法，使用一个大的，具有全国代表性的样本可以更好地解释transdiagnosis性质的后果早发性publication.MethodsData的初潮和精神障碍的年龄从一个人口代表性的样本的青少年（n = 4925），年龄13-17。采用因子分析拟合四种潜在障碍类别：痛苦、进食、外化和恐惧障碍。相对于平均初潮时间（12岁）的受试者，初潮时间包括较早（年龄≤ 10岁，11岁）和较晚（13岁，14岁以上）的受试者。月经初潮和潜伏性疾病的时间之间的关联估计在结构方程模型（SEM），调整年龄，收入，种族，父母的婚姻状况，体重指数，和童年advertisement.ResultsThe测量模型证明可接受的适合（CFI = 0.91; RMSEA = 0.02）。与月经初潮准时或推迟相比，11岁之前月经初潮与痛苦障碍（系数= 0.096; p < 0.0001）、恐惧障碍（系数= 0.09; p < 0.0001）和外化障碍（系数= 0.039; p = 0.049）显著相关。没有残留关联的初潮与个别疾病以上的潜伏disorders.ConclusionThe潜在的建模方法照亮有意义的transdiagnosis精神协会初潮的早期时机。青春期启动的生物过程可以影响青少年的认知和情感过程以及社会关系。在正常发育条件下，这些变化可能是适应性的。然而，对于那些与同龄人不同步的人来说，研究人员和临床医生应该认识到这些过程有可能影响青春期对一系列广泛的精神病理学后果的责任。
BackgroundEarlier age of pubertal maturation in females is associated with increased risk for mental health problems in adolescence, compared with on-time or later maturation. However, most investigations of pubertal timing and mental health consider risk for individual disorders and fail to account for comorbidity. A latent-modeling approach using a large, nationally representative sample could better explain the transdiagnostic nature of the consequences of early-onset puberty.MethodsData on age of menarche and mental disorders were drawn from a population-representative sample of adolescents (n = 4925), ages 13–17. Confirmatory factor analysis was used to fit four latent disorder categories: distress, eating, and externalizing, and fear disorders. Timing of menarche included those with earlier (age ≤ 10, age 11) and later age of onset (age 13, 14 +), relative to those with average timing of menarche (age 12). Associations between timing of menarche and latent disorders were estimated in a structural equation model (SEM), adjusted for age, income, race, parent marital status, BMI, and childhood adversity.ResultsThe measurement model evidenced acceptable fit (CFI = 0.91; RMSEA = 0.02). Onset of menarche before age 11 was significantly associated with distress disorders (coefficient = 0.096; p < 0.0001), fear disorders (coefficient = 0.09; p < 0.0001), and externalizing disorders (coefficient = 0.039; p = 0.049) as compared to on-time or late menarche. No residual associations of early menarche with individual disorders over and above the latent disorders were observed.ConclusionThe latent modeling approach illuminated meaningful transdiagnostic psychiatric associations with early timing of menarche. Biological processes initiated at puberty can influence cognitive and affective processes as well as social relationships for adolescents. Under developmentally normative conditions, these changes may be adaptive. However, for those out of sync with their peers, researchers and clinicians should recognize the potential for these processes to influence liability to a broad array of psychopathological consequences in adolescence.