No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents
No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents
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DOI：
10.3233/jad-131841
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发表时间：
2014-01-01
影响因子：
4
通讯作者：
Simmons, Andrew
中科院分区：
文献类型：
--
作者：
Khan, Wasim;Giampietro, Vincent;Simmons, Andrew
已知载脂蛋白E（ApoE）基因的等位基因调节发生迟发性阿尔茨海默病（AD）的遗传风险，并且与AD中的海马体积差异相关。然而，这些等位基因对年轻受试者海马体积的影响尚未明确。这项研究使用了一个超过1,400名青少年的大型队列，没有发现ApoE ε 4或ε 2等位基因携带者和非携带者之间的海马体积或海马不对称性差异，也没有任何等位基因的剂量依赖性效应，这表明这些多态性的区域特异性效应可能只在以后的生活中才变得明显。
Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE epsilon 4 or epsilon 2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.