CONGENITAL SUSCEPTIBILITY TO NIDDM - ROLE OF INTRAUTERINE ENVIRONMENT
CONGENITAL SUSCEPTIBILITY TO NIDDM - ROLE OF INTRAUTERINE ENVIRONMENT
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DOI：
10.2337/diabetes.37.5.622
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发表时间：
1988-05-01
期刊：
影响因子：
7.7
通讯作者：
KNOWLER, WC
中科院分区：
文献类型：
--
作者：
PETTITT, DJ;ALECK, KA;KNOWLER, WC
皮马印第安妇女怀孕期间非胰岛素依赖型糖尿病（NIDDM）导致其后代在20-24岁时的NIDDM患病率（45%）高于非糖尿病妇女（1.4%）或糖尿病前期妇女（8.6%）的后代，即仅在怀孕后才患糖尿病的妇女。在考虑了父亲患糖尿病、父母患糖尿病的年龄以及后代的体重与身高之比后，这些差异依然存在。研究结果表明，宫内环境是糖尿病发展的重要决定因素，其影响除了遗传因素的影响外。
Non-insulin-dependent diabetes mellitus (NIDDM) during pregnancy in Pima Indian women results in offspring who have a higher prevalence of NIDDM (45%) at age 20-24 yr than in offspring of nondiabetic women (1.4%) or offspring of prediabetic women (8.6%), i.e., women who developed diabetes only after the pregnancy. These differences persist after taking into account paternal diabetes, age at onset of diabetes in the parents, and the offspring''s weight relative to height. The findings suggest that the intrauterine environment is an important determinant of the development of diabetes and that its effect is in addition to effects of genetic factors.