ANTICHLAMYDIAL ACTIVITY OF VAGINAL SECRETION
ANTICHLAMYDIAL ACTIVITY OF VAGINAL SECRETION
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DOI：
10.1016/0002-9378(95)91491-9
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发表时间：
1995-04-01
影响因子：
9.8
通讯作者：
MARDH, PA
中科院分区：
文献类型：
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作者：
MAHMOUD, EA;SVENSSON, LO;MARDH, PA
目的：探讨阴道分泌物可能具有的抗沙眼衣原体活性，并对其抑制原理进行部分表征。研究设计：研究156例计划生育或妇科门诊寻求避孕建议的妇女的阴道分泌物对环己亚胺处理的McCoy细胞培养中沙眼衣原体包涵体形成的影响。结果：156例妇女阴道分泌物抑制沙眼衣原体包涵体的形成。抑制作用呈浓度依赖性，其抑制原理为相对分子质量为6为33%。口服避孕药使用者和非使用者的阴道分泌物减少衣原体包涵体数量的能力无差异，p>；0.01。结论：在感染沙眼衣原体的McCoy细胞培养物中加入阴道分泌物后，衣原体包涵体数量减少。阴道分泌物的pH值与抑制原理有关。口服避孕药的使用对抑制作用无影响。
OBJECTIVE: The purpose of this study was to investigate the possible antichlamydial activity of vaginal secretion and to partially characterize the inhibitory principle.STUDY DESIGN: Vaginal secretions obtained from 156 women attending a family planning or gynecologic outpatient clinic for contraceptive advice were studied for the influence on the inclusion formation of Chlamydia trachomatis in cycloheximide-treated McCoy cell cultures.RESULTS: Vaginal secretions from 156 women inhibited the inclusion formation of Chlamydia trachomatis. The inhibition was concentration dependent and the inhibitory principle had a molecular weight of 6 was 33%. Vaginal secretions of oral contraceptive users and nonusers did not differ in the capacity to decrease the chlamydial inclusion count, p > 0.01.CONCLUSIONS: When vaginal secretions were added to McCoy cell cultures infected by Chlamydia trachomatis, the chlamydia inclusion number decreased. There was a correlation between pH of the vaginal secretion and the inhibitory principle. Oral contraceptive use had no influence on the inhibition.