Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the Third National Health and Nutrition Examination Survey
Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the Third National Health and Nutrition Examination Survey
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DOI：
10.1093/aje/153.5.424
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发表时间：
2001-03-01
影响因子：
5
通讯作者：
Wright, JD
中科院分区：
文献类型：
--
作者：
Mares-Perlman, JA;Fisher, AI;Wright, JD
研究了40岁以上人群(n=8,222)饮食和血清中类胡萝卜素、叶黄素和玉米黄质与早、晚期老年性黄斑病变(ARM)的摄影证据之间的关系。饮食或血清中的这些类胡萝卜素与任何形式的手臂没有总体上的反向关系。饮食水平与早期手臂的一种类型(软性玻璃体)有直接关系。然而，两人的关系因年龄和种族而异。在有早期(40-59岁)或晚期(60-79岁)ARM风险的最年轻年龄组中，饮食中叶黄素和玉米黄质水平较高与色素异常的风险较低有关，在调整了年龄、性别、饮酒、高血压、吸烟和体重指数后，这是早期ARM(高与低五分位数的人的优势比=0.1，95%可信区间：0.1，0.3)和晚期ARM(优势比=0.1，95%可信区间：0.0，0.9)的一个迹象。这些类胡萝卜素与ARM的关系可能会受到年龄和种族的影响，需要在不同的人群中和前瞻性研究中进一步评估。
Relations of the carotenoids lutein and zeaxanthin in the diet and serum to photographic evidence of early and late age-related maculopathy (ARM) among persons over age 40 years (n = 8,222) were examined. Inverse relations of these carotenoids in the diet or serum to any form of ARM were not observed overall. There was a direct relation of dietary levels to one type of early ARM (soft drusen). However, relations differed by age and race. In the youngest age groups who were at risk for developing early (ages 40-59 years) or late (ages 60-79 years) ARM, higher levels of lutein and zeaxanthin in the diet were related to lower odds for pigmentary abnormalities, one sign of early ARM (odds ratio among persons in high vs. low quintiles = 0.1, 95 percent confidence interval: 0.1, 0.3) and of late ARM (odds ratio = 0.1, 95 percent confidence interval: 0.0, 0.9) after adjustment for age, gender, alcohol use, hypertension, smoking, and body mass index. Relations of these carotenoids to ARM may be influenced by age and race and require further evaluation in separate populations and in prospective studies.