RESPIRATORY SYNCYTIAL VIRUS-INFECTIONS IN INFANTS - QUANTITATION AND DURATION OF SHEDDING
RESPIRATORY SYNCYTIAL VIRUS-INFECTIONS IN INFANTS - QUANTITATION AND DURATION OF SHEDDING
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DOI：
10.1016/s0022-3476(76)80918-3
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发表时间：
1976-01-01
影响因子：
5.1
通讯作者：
GEIMAN, JM
中科院分区：
文献类型：
--
作者：
HALL, CB;DOUGLAS, RG;GEIMAN, JM
对呼吸道合胞病毒（RSV）感染住院的婴儿进行了研究，以确定RSV的定量脱落模式和脱落持续时间。每天采集的19例婴儿鼻洗液标本中，平均最大滴度为4.34 log10 50%组织培养感染剂量[TCID50]/ml。入院时，平均滴度为4.14 log10 TCID50，直到第6天才出现持续下降。23例患者的平均脱落时间为6.7天，直至病毒阴性，范围为1-21天。在小于1岁的婴儿和胸片上有肺实变证据的婴儿中，RSV的数量显著增加。患有下呼吸道疾病的婴儿的脱落时间明显长于那些临床表现仅限于上呼吸道的婴儿。
Infants hospitalized with respiratory syncytial virus [RSV] infection were studied to delineate the quantitative shedding patterns and duration of shedding of RSV. Nasal wash specimens collected daily from 19 infants contained a mean maximal titer of 4.34 log10 50% tissue culture infective doses [TCID50]/ml. On admission, the mean titer was 4.14 log10 TCID50, with no consistent decline until after day 6. The mean duration of shedding for 23 patients until they were virus negative was 6.7 days with a range of 1-21 days. Quantities of RSV shed were significantly greater in infants < 1 mo. and in infants with evidence of pulmonary consolidation on chest roentgenogram. Shedding extended for a significantly longer time in infants with lower respiratory tract disease than in those with clinical manifestations limited to the upper respiratory tract.