Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort.
Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort.
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ADNI 队列中的睡眠障碍和认知下降或临床转变的风险。
DOI：
10.1159/000488671
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发表时间：
2018
影响因子：
2.4
通讯作者：
The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
中科院分区：
文献类型：
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作者：
Mecca,AdamP;Michalak,HannahR;McDonald,JuliaW;Kemp,EmilyC;Pugh,ErikaA;Becker,MelindaL;Mecca,MarciaC;vanDyck,ChristopherH;The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
背景：我们调查了认知正常个体(CN)、轻度认知障碍(MCI)和阿尔茨海默病痴呆(AD-Demania)患者的睡眠障碍与认知功能下降或临床转换的关系。方法：对1,629名年龄在48岁至91岁之间的成年人进行二次分析，并对ADNI(阿尔茨海默病神经成像计划)进行了长达24个月的随访。结果：睡眠障碍与记忆、执行功能或整体认知能力的下降无关。睡眠障碍的存在不会显著增加CN、早期MCI或晚期MCI患者诊断转换的风险。结论：本研究使用几种结果研究了睡眠障碍对认知下降的影响，并不支持睡眠障碍预测随后认知下降的假设。
Background:We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia).Methods:Secondary analysis of 1,629 adults between 48 and 91 years of age with up to 24 months of follow-up from the ADNI (Alzheimer’s Disease Neuroimaging Initiative), a longitudinal cohort study.Results:Sleep disturbance was not associated with decline in memory, executive function, or global cognition. The presence of sleep disturbance did not significantly increase the risk of diagnostic conversion in CN, early MCI, or late MCI participants.Conclusion:This study investigated the effect of sleep disturbance on cognitive decline using several outcomes and does not support the hypothesis that sleep disturbance predicts subsequent cognitive decline.