A modular, closed-loop platform for intracranial stimulation in people with neurological disorders.
A modular, closed-loop platform for intracranial stimulation in people with neurological disorders.
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DOI：
10.1109/embc.2016.7591394
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Truccolo W
中科院分区：
文献类型：
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作者：
Sarma AA;Crocker B;Cash SS;Truccolo W
基于电刺激的神经调节系统可用于研究、探测和潜在地治疗一系列神经障碍。正在进行的神经状态和动力学对刺激响应的影响，以及刺激参数对神经状态的影响，对闭环神经调节方法的发展具有广泛的意义。我们描述了一个模块化的，低延迟平台的临床前，闭环神经调节研究与人类参与者的发展。我们说明了使用的平台，在刺激的情况下进行神经监测切除手术前与癫痫患者的研究。我们证明了该系统的有效性，通过跟踪发作间期癫痫样放电的局部场电位触发颅内电刺激，并表明刺激的反应取决于神经状态。
Neuromodulation systems based on electrical stimulation can be used to investigate, probe, and potentially treat a range of neurological disorders. The effects of ongoing neural state and dynamics on stimulation response, and of stimulation parameters on neural state, have broad implications for the development of closed-loop neuromodulation approaches. We describe the development of a modular, low-latency platform for pre-clinical, closed-loop neuromodulation studies with human participants. We illustrate the uses of the platform in a stimulation case study with a person with epilepsy undergoing neuro-monitoring prior to resective surgery. We demonstrate the efficacy of the system by tracking interictal epileptiform discharges in the local field potential to trigger intracranial electrical stimulation, and show that the response to stimulation depends on the neural state.