Symptomatic and functional outcome in youth at ultra-high risk for psychosis: A longitudinal study
Symptomatic and functional outcome in youth at ultra-high risk for psychosis: A longitudinal study
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DOI：
10.1016/j.schres.2009.09.011
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发表时间：
2009-12-01
影响因子：
4.5
通讯作者：
Angel Ortega-Ferrandez, Jose
中科院分区：
文献类型：
--
作者：
Lemos-Giraldez, Serafin;Vallina-Fernandez, Oscar;Angel Ortega-Ferrandez, Jose
目前的报告评估了参加P3精神病预防计划的一个队列的临床，功能和人口统计学数据;西班牙国家卫生系统和科学部资助的计划。在平均24次治疗后的3年内，对那些已经转化为精神病的人和那些没有转化为精神病的人进行了比较。受试者包括61名符合前驱综合征标准的参与者，年龄从17岁到31岁不等，所有人都符合超高风险精神病的标准。报告了在I年和3年时重新评价的患者的前瞻性随访Lip数据。在1年随访时，精神病的转化率为18%，但在3年随访时增加到23%。转换的样本比未转换的样本年龄更大，并且更可能在亚综合征精神病（阳性和紊乱），阴性和一般症状方面具有更高的评级，并且在基线评估时功能水平较低。随时间变化的分析表明，在临床稳定的患者和那些谁表现出短暂的精神病状态随着时间的推移，一个明确的临床改善。在三个随访时间点，没有发现症状或功能水平的性别差异;然而，转换率x性别x SOP总分x时间点之间的相互作用显著反映了四组的生长特征（无转换男性，无转换女性，转换男性和转换女性）在SOPS总分中不平行，因此，这四个组涉及不同的变化模式，随着时间的推移，男性经历更快和更长的恶化时，精神病症状出现。(C)2009 Elsevier B. V.保留所有权利。
The Current report assesses the clinical, functioning and demographic data of a cohort enrolled in the P3 prevention program for psychosis; a Spanish National Health System and Ministry of Science funded program. Comparisons are made between those individuals who had converted to psychosis and those who had not at 3 years after an average of 24 treatment sessions. Subjects included 61 participants meeting Structured Interview for Prodromal Syndromes criteria, with ages ranging from 17 to 31, and all meeting criteria for ultra-high risk of psychosis. Prospective follow-Lip data are reported for patients re-evaluated at I and 3 years. At I-year follow-up, the conversion rate to psychosis was 18%, but increased to 23% at 3-year follow-up. The converted sample was older than the non-converted sample and more likely to have higher ratings on subsyndromal psychotic (positive and disorganized), negative and general symptoms, and lower levels of functioning at baseline assessment. Analyses of change over time indicated a clear clinical improvement in both clinically stable patients and in those who showed a transient psychotic state over time. No gender differences in symptom or functioning levels at the three follow-up time points were found; however, the interactions among conversion x gender x SOPS total score x time points significantly reflect that the growth profiles of the four groups (no conversion males, no conversion females, conversion males and conversion females) in the SOPS total score are not parallel and that, consequently, the four groups involved different patterns of change over time, males experiencing faster and longer deterioration when psychotic symptoms arise. (C) 2009 Elsevier B.V. All rights reserved.