Cord Blood Levels of Toxic and Essential Trace Elements and Their Determinants in the Terai Region of Nepal: A Birth Cohort Study
Cord Blood Levels of Toxic and Essential Trace Elements and Their Determinants in the Terai Region of Nepal: A Birth Cohort Study
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DOI：
10.1007/s12011-011-9309-1
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发表时间：
2012-06-01
影响因子：
3.9
通讯作者：
Watanabe, Chiho
中科院分区：
文献类型：
--
作者：
Parajuli, Rajendra Prasad;Fujiwara, Takeo;Watanabe, Chiho
本研究的目的是评估尼泊尔特莱地区脐带血中有毒元素和微量元素的水平，并确定其决定因素。 2008 年，尼泊尔奇特旺的一家医院招募了 100 名孕妇。对脐带血中有毒物质 [铅 (Pb)、砷 (As) 和镉 (Cd)]、必需微量元素 [锌 (Zn)、硒 (Se) 和铜 (Cu)] 的水平以及人口、社会经济和行为变量进行了测量。脐带血中 Pb、As、Cd、Zn、Se 和 Cu 的平均值分别为 31.7、1.46、0.39、2,286、175 和 667 μg/L。在多元回归模型中，受教育程度较低的母亲的脐带血 As 水平高于受教育程度的母亲（系数 = -0.01，95% 置信区间 [CI] = -0.02-0.00）。母亲年龄与脐带血Cd水平呈正相关（系数=0.02，95%CI=0.01-0.03），而与脐带血As水平呈负相关（系数=-0.01，95%CI=-0.03--0.01）。脐带血中铅、锌、硒和铜的水平与母亲年龄、社会经济地位、生活环境和吸烟状况无关。砷和镉的含量相对低于亚洲先前研究报告的水平，而铅和微量元素的含量相似。在尼泊尔特莱，受教育程度较低的母亲更有可能在子宫内摄入较高的镉，而高龄母亲的胎儿更有可能在子宫内接触镉较高。
The purpose of this study is to evaluate the cord blood level of toxic and trace elements and to identify their determinants in Terai, Nepal. One hundred pregnant women were recruited from one hospital in Chitwan, Nepal in 2008. The cord blood levels of toxic [lead (Pb), arsenic (As), and cadmium (Cd)], essential trace elements [zinc (Zn), selenium (Se), and copper (Cu)], demographic, socioeconomic, and behavioral variables were measured. The mean values of Pb, As, Cd, Zn, Se, and Cu in cord blood level were found as 31.7, 1.46, 0.39, 2,286, 175, and 667 mu g/L, respectively. In the multivariate regression model, cord blood As levels from less educated mothers were higher than those from educated mothers (coefficient = -0.01, 95% confidence interval [CI] = -0.02-0.00). The maternal age was positively associated with the cord blood Cd level (coefficient = 0.02, 95% CI = 0.01-0.03), while it was negatively associated with the cord blood As level (coefficient = -0.01, 95% CI = -0.03--0.01). Cord blood levels of Pb, Zn, Se, and Cu were not associated with maternal age, socioeconomic status, living environment, and smoking status. As and Cd levels were relatively lower than those reported in previous studies in Asia, while the levels of Pb and the trace elements were similar. Less educated mothers are more likely to become a higher in utero As source to their fetus, and fetuses of older mothers were more likely to have higher in utero Cd exposure in Terai, Nepal.