Lulling the Cancer Cell into an Eternal Sleep.
Lulling the Cancer Cell into an Eternal Sleep.
复制标题
让癌细胞陷入永恒的睡眠。
DOI：
10.1158/0008-5472.can-19-0853
复制
发表时间：
2019
期刊：
影响因子：
11.2
通讯作者：
Narla,Goutham
中科院分区：
文献类型：
--
作者：
Farrington,CarolineC;Narla,Goutham
转移的标志是癌细胞经历上皮向间充质转化以侵入和扩散到远端部位的能力。最近，已经证明转移的关键最后一步取决于在称为间充质-上皮转化（MET）的过程中经历上皮表型逆转的能力。正是这种转移级联的转变，研究人员正在临床上关注治疗播散性疾病。Shinde及其同事将脾酪氨酸激酶（SYK）确定为MET的关键介质，促进自噬期间P体的去除。值得注意的是，SYK的药理学抑制在转移的临床前模型中抑制P体和自噬的清除，阻止癌细胞处于无限期休眠状态并防止肿瘤细胞定植，从而防止侵袭性转移性疾病的建立。第1831页
A hallmark of metastasis is the ability of cancer cells to undergo the epithelial-to-mesenchymal transition to invade and disseminate to distal sites. More recently, the case has been made that the critical last step in metastasis is dependent on the ability to undergo reversion to an epithelial phenotype in a process known as the mesenchymal-to-epithelial transition (MET). It is this transition in the metastatic cascade that researchers are focusing on clinically to treat disseminated disease. Shinde and colleagues identified spleen tyrosine kinase (SYK) as a critical mediator of MET that facilitated the removal of P-bodies during autophagy. Remarkably, pharmacologic inhibition of SYK inhibited the clearance of P-bodies and autophagy in preclinical models of metastasis, arresting cancer cells in an indefinite dormant state and preventing tumor cell colonization and thus the establishment of aggressive metastatic disease.See related article by Shinde et al., p. 1831