The Role of Tea in Human Health: An Update
The Role of Tea in Human Health: An Update
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DOI：
10.1080/07315724.2002.10719187
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发表时间：
2002-02
影响因子：
3.5
通讯作者：
Diane L McKay;J. Blumberg
中科院分区：
文献类型：
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作者：
Diane L McKay;J. Blumberg
茶是黄烷醇和黄酮醇的重要膳食来源。在体外和动物实验中，茶多酚具有生物活性，可影响多种慢性疾病的发病机制，尤其是心血管疾病和癌症。然而，关于茶与健康之间关系的流行病学和临床研究结果喜忧参半。国际相关性并不支持这种关系，尽管一些控制更好的病例参考和队列研究表明与慢性病风险的适度降低有关。人类研究之间的差异可能部分来自社会经济和生活方式因素的混淆，以及定义茶制备和摄入的方法不充分。采用假定的疾病中介指标，特别是氧化应激状态的生物标志物的临床试验表明，茶多酚可能在癌症和心脏病的发病机制中发挥作用。
Tea is an important dietary source of flavanols and flavonols. In vitro and animal studies provide strong evidence that tea polyphenols may possess the bioactivity to affect the pathogenesis of several chronic diseases, especially cardiovascular disease and cancer. However, the results from epidemiological and clinical studies of the relationship between tea and health are mixed. International correlations do not support this relationship although several, better controlled case-referent and cohort studies suggest an association with a moderate reduction in the risk of chronic disease. Conflicting results between human studies may arise, in part, from confounding by socioeconomic and lifestyle factors as well as by inadequate methodology to define tea preparation and intake. Clinical trials employing putative intermediary indicators of disease, particularly biomarkers of oxidative stress status, suggest tea polyphenols could play a role in the pathogenesis of cancer and heart disease.